{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:18:14Z","timestamp":1792120694725,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009488","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000}}],"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus <jats:italic>Madurella mycetomatis<\/jats:italic>. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the <jats:italic>in vitro<\/jats:italic> activity of CIN-102 against 21 <jats:italic>M<\/jats:italic>. <jats:italic>mycetomatis<\/jats:italic> isolates and its <jats:italic>in vivo<\/jats:italic> efficacy in a <jats:italic>M<\/jats:italic>. <jats:italic>mycetomatis<\/jats:italic> infected <jats:italic>Galleria mellonella<\/jats:italic> larval model. <jats:italic>In vitro<\/jats:italic>, CIN-102 was active against <jats:italic>M<\/jats:italic>. <jats:italic>mycetomatis<\/jats:italic> with MICs ranging from 32 \u03bcg\/mL to 512 \u03bcg\/mL. 128 \u03bcg\/mL was needed to inhibit the growth in 50% of tested isolates. <jats:italic>In vivo<\/jats:italic>, concentrations below the MIC of 40 mg\/kg and 80 mg\/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009488","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T18:21:59Z","timestamp":1623262919000},"page":"e0009488","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma"],"prefix":"10.1371","volume":"15","author":[{"given":"Mickey","family":"Konings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Eadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H.","family":"Fahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Mouton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7263-7268","authenticated-orcid":true,"given":"Nicolas","family":"Tesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-8783","authenticated-orcid":true,"given":"Wendy W. 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