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The alarming number of dengue cases in Malaysia requires an alternative method to control dengue besides the traditional method such as fogging. However, the introduction of new technologies depends on social acceptance. Therefore, this study was important to determine the factors that influence stakeholders\u2019 attitudes towards the ORS and the moderating factor. A validated instrument was used to randomly interview 399 respondents representing two stakeholder groups which consist of scientists, and the public in Klang Valley, Malaysia. The findings revealed that the stakeholders claimed to have a high degree of religiosity, a high level of trust in the key players, perceived ORS as having high benefits, and displayed highly positive attitudes towards the ORS. The attitudes model towards the ORS model was developed using the SmartPLS software version. The perceived benefit was endorsed as the most important direct predictor of attitudes towards the ORS (\u00df = 0.618, P&lt;0.001), followed by trust in the key players (\u00df = 0.151, P&lt;0.001). It is also interesting to note that religiosity served as a moderator for the association between perceived benefit (\u00df = 0.075, P = 0.024) and perceived risk (\u00df = 0.114, P = 0.006) with attitudes towards the ORS. The identified predictor factors of stakeholders\u2019 attitudes toward the ORS and the moderating factor can serve as indicators for social acceptance of ORS in developing countries. These indicators can help the policymakers in decision making to implement this technique.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009493","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T17:22:12Z","timestamp":1624987332000},"page":"e0009493","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Stakeholders\u2019 attitudes to outdoor residual spraying technique for dengue control in Malaysia: A PLS-SEM approach"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-2077","authenticated-orcid":true,"given":"Ahmad Firdhaus","family":"Arham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifah","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1358-627X","authenticated-orcid":true,"given":"Muhammad Adzran Che","family":"Mustapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-7537","authenticated-orcid":true,"given":"Zurina","family":"Mahadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashitoh","family":"Yaacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-2265","authenticated-orcid":true,"given":"Maznah","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"issue":"5","key":"pntd.0009493.ref001","first-page":"777","article-title":"Dengue Vector Control in Malaysia: A Review for Current and Alternative Strategies","volume":"45","author":"SQ Ong","year":"2016","journal-title":"Sains Malaysiana"},{"issue":"1","key":"pntd.0009493.ref002","first-page":"11","article-title":"Dengue Vector Control in Malaysia-Challenges and Recent Advanced","volume":"14","author":"HL Lee","year":"2015","journal-title":"T Int Med J. 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