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To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009641","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T18:20:23Z","timestamp":1627669223000},"page":"e0009641","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-4577","authenticated-orcid":true,"given":"Chelsea M.","family":"Crooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-8235","authenticated-orcid":true,"given":"Andrea 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