{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:33:19Z","timestamp":1791865999959,"version":"4.3.4"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Schistosomiasis, also known as bilharzia, is a chronic parasitic blood fluke infection acquired through contact with contaminated surface water. The illness may be mild or can cause significant morbidity with potentially serious complications. Children and those living in rural areas with limited access to piped water and services for healthcare are the most commonly infected. To address the prevalence of the disease in parts of South Africa (SA) effective national control measures are planned, but have not yet been implemented. This study aimed to estimate the prevalence and trends of public sector laboratory-confirmed schistosomiasis cases in SA over an eight-year (2011\u20132018) period, to inform future control measures.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology &amp; principal findings<\/jats:title>\n<jats:p>This is a descriptive analysis of secondary data from the National Health Laboratory Service (NHLS). The study included all records of patients for whom microscopic examination detected <jats:italic>Schistosoma<\/jats:italic> species eggs in urine or stool specimens from January 2011 to December 2018. Crude estimates of the prevalence were calculated using national census mid-year provincial population estimates as denominators, and simple linear regression was used to analyse prevalence trends. A test rate ratio was developed to describe variations in testing volumes among different groups and to adjust prevalence estimates for testing variations.<\/jats:p>\n<jats:p>A total number of 135 627 schistosomiasis cases was analysed with the highest prevalence observed among males and individuals aged 5\u201319 years. We describe ongoing endemicity in the Eastern Cape Province, and indicate important differences in the testing between population groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>While there was no overall change in the prevalence of schistosomiasis during the analysis period, an average of 36 people per 100 000 was infected annually. As such, this represents an opportunity to control the disease and improve quality of life of affected people. Laboratory-based surveillance is a useful method for reporting occurrence and evaluating future intervention programs where resources to implement active surveillance are limited.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0009669","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T17:42:33Z","timestamp":1631814153000},"page":"e0009669","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011\u20132018"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-8699","authenticated-orcid":true,"given":"Liesl","family":"De Boni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Msimang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-5598","authenticated-orcid":true,"given":"Alex","family":"De Voux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-5760","authenticated-orcid":true,"given":"John","family":"Frean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"pntd.0009669.ref001","unstructured":"Frean, J. 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Kabuyaya","year":"2018","journal-title":"Infect Dis Poverty"},{"issue":"2","key":"pntd.0009669.ref040","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4269\/ajtmh.1981.30.364","article-title":"A cross-sectional study on the prevalence and intensity of infection with Schistosoma haematobium students of Northern KwaZulu","volume":"30","author":"C.H. Schutte","year":"1981","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"1","key":"pntd.0009669.ref041","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40249-017-0293-3","article-title":"Efficacy of praziquantel on Schistosoma haematobium and re-infection rates among school-going children in the Ndumo area of uMkhanyakude district, KwaZulu-Natal, South Africa","volume":"6","author":"M. Kabuyaya","year":"2017","journal-title":"Infect Dis Poverty"},{"key":"pntd.0009669.ref042","first-page":"1","article-title":"Review of literature on abiotic factors influencing the distribution and life cycles of bilharzia intermediate host snails","volume":"11","author":"C.C. Appleton","year":"1978","journal-title":"Malacological Review"},{"issue":"1","key":"pntd.0009669.ref043","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40249-017-0260-z","article-title":"Effect of temperature on the Bulinus globosus\u2014Schistosoma haematobium system","volume":"6","author":"C. Kalinda","year":"2017","journal-title":"Infect Dis Poverty"},{"issue":"9","key":"pntd.0009669.ref044","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15091884","article-title":"Impacts of Climate Change on Health and Wellbeing in South Africa","volume":"15","author":"M.F. Chersich","year":"2018","journal-title":"Int J Environ Res Public Health"},{"issue":"13","key":"pntd.0009669.ref045","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0031182009991600","article-title":"Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution","volume":"136","author":"J. Utzinger","year":"2009","journal-title":"Parasitology"},{"issue":"1","key":"pntd.0009669.ref046","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s40249-017-0370-7","article-title":"Elimination of schistosomiasis: the tools required","volume":"6","author":"R. Bergquist","year":"2017","journal-title":"Infect Dis Poverty"},{"key":"pntd.0009669.ref047","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijid.2016.09.023","article-title":"A new global strategy for the elimination of schistosomiasis","volume":"54","author":"A.G. 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