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We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology and principle findings<\/jats:title>\n<jats:p>This study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed.<\/jats:p>\n<jats:p>Approximately 17% of patients were positive for either ST (1,337\/8,150 patients tested) or MT (1,283\/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0009685","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T17:23:54Z","timestamp":1629912234000},"page":"e0009685","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-737X","authenticated-orcid":true,"given":"Tamalee","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-7338","authenticated-orcid":true,"given":"Daniel M.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Bulterys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-9281","authenticated-orcid":true,"given":"Sayaphet","family":"Rattanavong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-5449","authenticated-orcid":true,"given":"Ivo","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-0522","authenticated-orcid":true,"given":"Koukeo","family":"Phommasone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayfong","family":"Mayxay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilada","family":"Chansamouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-2712","authenticated-orcid":true,"given":"Matthew T.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-726X","authenticated-orcid":true,"given":"Stuart D.","family":"Blacksell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-6431","authenticated-orcid":true,"given":"Paul N.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"issue":"1","key":"pntd.0009685.ref001","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/S2214-109X(13)70008-1","article-title":"Causes of non-malarial fever in Laos: a prospective study","volume":"1","author":"M Mayxay","year":"2013","journal-title":"The Lancet Global health"},{"issue":"2","key":"pntd.0009685.ref002","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3201\/eid1202.050900","article-title":"Rickettsial infections and fever, Vientiane, Laos","volume":"12","author":"S Phongmany","year":"2006","journal-title":"Emerging infectious diseases"},{"issue":"8","key":"pntd.0009685.ref003","doi-asserted-by":"crossref","first-page":"e0003971","DOI":"10.1371\/journal.pntd.0003971","article-title":"A Systematic Review of Mortality from Untreated Scrub Typhus (Orientia tsutsugamushi)","volume":"9","author":"AJ Taylor","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pntd.0009685.ref004","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1086\/527443","article-title":"Murine typhus: an unrecognized suburban vectorborne disease","volume":"46","author":"R Civen","year":"2008","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America."},{"key":"pntd.0009685.ref005","unstructured":"Lao Statistics Bureau. 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