{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:56:47Z","timestamp":1773287807721,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pntd.0009687","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000}}],"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016341","name":"Korea University Guro Hospital","doi-asserted-by":"crossref","award":["I1602131"],"award-info":[{"award-number":["I1602131"]}],"id":[{"id":"10.13039\/100016341","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>With global warming and lush forest change, vector-borne infections are expected to increase in the number and diversity of agents. Since the first report of severe fever with thrombocytopenia syndrome (SFTS) in 2013, the number of reported cases has increased annually in South Korea. However, although tick-borne encephalitis virus (TBEV) was detected from ticks and wild rodents, there is no human TBE case report in South Korea. This study aimed to determine the seroprevalence of TBEV and SFTS virus (SFTSV) among forest and field workers in South Korea. From January 2017 to August 2018, a total 583 sera were obtained from the forest and field workers in South Korea. IgG enzyme-linked immunosorbent assay (ELISA) and neutralization assay were conducted for TBEV, and indirect immunofluorescence assay (IFA) and neutralization assay were performed for SFTSV. Seroprevalence of TBEV was 0.9% (5\/583) by IgG ELISA, and 0.3% (2\/583) by neutralization assay. Neutralizing antibody against TBEV was detected in a forest worker in Jeju (1:113) and Hongcheon (1:10). Only 1 (0.2%) forest worker in Yeongju was seropositive for SFTSV by IFA (1:2,048) and neutralizing antibody was detected also. In conclusion, this study shows that it is necessary to raise the awareness of physicians about TBEV infection and to make efforts to survey and diagnose vector-borne diseases in South Korea.<\/jats:p>","DOI":"10.1371\/journal.pntd.0009687","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T18:05:56Z","timestamp":1629309956000},"page":"e0009687","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Seroepidemiologic survey of emerging vector-borne infections in South Korean forest\/field workers"],"prefix":"10.1371","volume":"15","author":[{"given":"Ji Yun","family":"Noh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-7194","authenticated-orcid":true,"given":"Joon Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Yong","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-486X","authenticated-orcid":true,"given":"Man-Seong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-1880","authenticated-orcid":true,"given":"Jin Gu","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4546-3880","authenticated-orcid":true,"given":"Woo Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"pntd.0009687.ref001","first-page":"1892","article-title":"Severe fever with thrombocytopenia syndrome, South Korea, 2012","volume":"19","author":"KH Kim","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"pntd.0009687.ref002","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3201\/eid2010.131680","article-title":"Human granulocytic anaplasmosis, South Korea, 2013","volume":"20","author":"KH Kim","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"pntd.0009687.ref003","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1128\/JCM.40.8.3082-3085.2002","article-title":"Serologic and molecular detection of Ehrlichia chaffeensis and Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) in Korean patients","volume":"40","author":"EJ Heo","year":"2002","journal-title":"J Clin Microbiol"},{"key":"pntd.0009687.ref004","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3947\/ic.2013.45.4.446","article-title":"First case of Bartonella henselae bacteremia in Korea","volume":"45","author":"JH Im","year":"2013","journal-title":"Infect Chemother"},{"key":"pntd.0009687.ref005","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S1473-3099(15)00177-2","article-title":"Emerging tick-borne infections in mainland China: an increasing public health threat","volume":"15","author":"LQ Fang","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"pntd.0009687.ref006","doi-asserted-by":"crossref","first-page":"430","DOI":"10.12998\/wjcc.v3.i5.430","article-title":"Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management","volume":"3","author":"P Bogovic","year":"2015","journal-title":"World J Clin Cases"},{"key":"pntd.0009687.ref007","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1038\/emi.2017.69","article-title":"Tick-borne encephalitis in Japan, Republic of Korea and China","volume":"6","author":"K Yoshii","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"pntd.0009687.ref008","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1128\/jvi.71.4.2921-2927.1997","article-title":"Pre- and postexposure protection by passive immunoglobulin but no enhancement of infection with a flavivirus in a mouse model","volume":"71","author":"TR Kreil","year":"1997","journal-title":"J Virol"},{"key":"pntd.0009687.ref009","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0092-1157(86)90032-6","article-title":"A model study of the use of monoclonal-antibodies in capture enzyme immunoassays for antigen quantification exploiting the epitope map of tick-borne encephalitis-virus","volume":"14","author":"FX Heinz","year":"1986","journal-title":"J Biol Stand"},{"key":"pntd.0009687.ref010","first-page":"227","article-title":"The Method of \u2019Right and Wrong Cases\u2019 (\u2019Constant Stimuli\u2019) without Gauss\u2019s Formulae","volume":"2","author":"C. 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