{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:53:43Z","timestamp":1784872423049,"version":"3.55.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p><jats:italic>Vancomycin-resistant enterococci<\/jats:italic> infection is a worrying worldwide clinical problem. To evaluate the accuracy of <jats:italic>GeneXpert vanA\/vanB<\/jats:italic> in the diagnosis of VRE, we conducted a systematic review in the study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Experimental data were extracted from publications until May 03 2021 related to the diagnostic accuracy of <jats:italic>GeneXpert vanA\/vanB<\/jats:italic> for <jats:italic>VRE<\/jats:italic> in PubMed, Embase, Web of Science and the Cochrane Library. The accuracy of <jats:italic>GeneXpert vanA\/vanB<\/jats:italic> for <jats:italic>VRE<\/jats:italic> was evaluated using summary receiver to operate characteristic curve, pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>8 publications were divided into 3 groups according to two golden standard references, <jats:italic>vanA<\/jats:italic> and <jats:italic>vanB<\/jats:italic> group, <jats:italic>vanA<\/jats:italic> group, <jats:italic>vanB<\/jats:italic> group, including 6 researches, 5 researches and 5 researches, respectively. The pooled sensitivity and specificity of group <jats:italic>vanA<\/jats:italic> and <jats:italic>vanB<\/jats:italic> were 0.96 (95% CI, 0.93\u20130.98) and 0.90 (95% CI, 0.88\u20130.91) respectively. The DOR was 440.77 (95% CI, 37.92\u20135123.55). The pooled sensitivity and specificity of group <jats:italic>vanA<\/jats:italic> were 0.86 (95% CI, 0.81\u20130.90) and 0.99 (95% CI, 0.99\u20130.99) respectively, and those of group <jats:italic>vanB<\/jats:italic> were 0.85 (95% CI, 0.63\u20130.97) and 0.82 (95% CI, 0.80\u20130.83) respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p><jats:italic>GeneXpert vanA\/vanB<\/jats:italic> can diagnose <jats:italic>VRE<\/jats:italic> with high-accuracy and shows greater accuracy in diagnosing <jats:italic>vanA<\/jats:italic>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0009869","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T18:22:32Z","timestamp":1636395752000},"page":"e0009869","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of GeneXpert vanA\/vanB in the early diagnosis of 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