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However, whether <jats:italic>Ascaris<\/jats:italic> larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of <jats:italic>Ascaris<\/jats:italic> larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of <jats:italic>Ascaris<\/jats:italic> larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010050","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T18:54:40Z","timestamp":1639680880000},"page":"e0010050","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in 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