{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:35:14Z","timestamp":1792802114870,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010135","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"European Union, DENCO project","award":["INCO-CT-2004-517708"],"award-info":[{"award-number":["INCO-CT-2004-517708"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R010161\/1"],"award-info":[{"award-number":["MR\/R010161\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T001267\/1"],"award-info":[{"award-number":["MR\/T001267\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Following earlier trials indicating that their potential in dengue vector control was constrained by housing structure, a large-scale cluster-randomized trial of insecticide treated curtains (ITCs) and water jar covers (ITJCs) was undertaken in Venezuela.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In Trujillo, Venezuela, 60 clusters (6223 houses total) were randomized so that 15 clusters each received either PermaNet insecticide-treated window curtains (ITCs), permanent insecticide-treated water storage jar covers (ITJCs), a combination of both ITCs and ITJCs, or no insecticide treated materials (ITMs). A further 15 clusters located at least 5km from the edge of the study site were selected to act as an external control. Entomological surveys were carried out immediately before and after intervention, and then at 6-month intervals over the following 27 months. The Breteau and House indices were used as primary outcome measures and ovitrap indices as secondary. Negative binomial regression models were used to compare cluster-level values of these indices between the trial arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reductions in entomological indices followed deployment of all ITMs and throughout the trial, indices in the external control arm remained substantially higher than in the ITM study arms including the internal control. Comparing the ratios of between-arm means to summarise the entomological indices throughout the study, the combined ITC+ITJC intervention had the greatest impact on the indices, with a 63% difference in the pupae per person indices between the ITC+ITJC arm and the internal control. However, coverage had fallen below 60% by 14-months post-intervention and remained below 40% for most of the remaining study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ITMs can impact dengue vector populations in the long term, particularly when ITCs and ITJCs are deployed in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/ISRCTN08474420\" xlink:type=\"simple\">ISRCTN08474420<\/jats:ext-link>\n                      ;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isrctn.com\" xlink:type=\"simple\">www.isrctn.com<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0010135","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T13:39:28Z","timestamp":1646401168000},"page":"e0010135","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-4228","authenticated-orcid":true,"given":"Audrey","family":"Lenhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Elena","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elci","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-7876","authenticated-orcid":true,"given":"Neal","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-0793","authenticated-orcid":true,"given":"Veerle","family":"Vanlerberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"van der Stuyft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-3985","authenticated-orcid":true,"given":"Philip J.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"issue":"7446","key":"pntd.0010135.ref001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"pntd.0010135.ref002","unstructured":"WHO: Dengue and Severe Dengue Factsheet. 2013."},{"key":"pntd.0010135.ref003","unstructured":"World Urbanization Prospects 2018. https:\/\/population.un.org\/wup\/ Accessed 18 September 2020."},{"issue":"5","key":"pntd.0010135.ref004","first-page":"619","article-title":"Effectiveness of peridomestic space spraying with insecticide on dengue transmission; systematic review","volume":"15","author":"E Esu","year":"2010","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"5","key":"pntd.0010135.ref005","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/tmi.12087","article-title":"Bacillus thuringiensis israelensis (Bti) for the control of dengue vectors: systematic literature review","volume":"18","author":"R Boyce","year":"2013","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"12","key":"pntd.0010135.ref006","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/j.1365-3156.2009.02396.x","article-title":"Multi-modal Aedes aegypti mosquito reduction interventions and dengue fever prevention","volume":"14","author":"KK Ballenger-Browning","year":"2009","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"3","key":"pntd.0010135.ref007","doi-asserted-by":"crossref","first-page":"e0004551","DOI":"10.1371\/journal.pntd.0004551","article-title":"Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis","volume":"10","author":"LR Bowman","year":"2016","journal-title":"PLoS neglected tropical diseases"},{"issue":"1","key":"pntd.0010135.ref008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/jmedent\/41.5.65","article-title":"Spatial and temporal patterns in the recovery of Aedes aegypti (Diptera: Culicidae) populations after insecticide treatment","volume":"44","author":"CJ Koenraadt","year":"2007","journal-title":"Journal of Medical Entomology"},{"issue":"7552","key":"pntd.0010135.ref009","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1136\/bmj.332.7552.1247","article-title":"Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials","volume":"332","author":"A Kroeger","year":"2006","journal-title":"BMJ"},{"issue":"1","key":"pntd.0010135.ref010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-3156.2007.01966.x","article-title":"Insecticide-treated bednets to control dengue vectors: preliminary evidence from a controlled trial in Haiti","volume":"13","author":"A Lenhart","year":"2008","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"3","key":"pntd.0010135.ref011","doi-asserted-by":"crossref","first-page":"e994","DOI":"10.1371\/journal.pntd.0000994","article-title":"Evaluation of the effectiveness of insecticide treated materials for household level dengue vector control","volume":"5","author":"V Vanlerberghe","year":"2011","journal-title":"PLoS neglected tropical diseases"},{"key":"pntd.0010135.ref012","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1186\/1471-2458-12-931","article-title":"Dengue vector management using insecticide treated materials and targeted interventions on productive breeding-sites in Guatemala","volume":"12","author":"N Rizzo","year":"2012","journal-title":"BMC public health"},{"issue":"2","key":"pntd.0010135.ref013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/trstmh\/tru208","article-title":"Effectiveness and feasibility of long-lasting insecticide-treated curtains and water container covers for dengue vector control in Colombia: a cluster randomised trial","volume":"109","author":"J Quintero","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"pntd.0010135.ref014","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4269\/ajtmh.2012.12-0423","article-title":"A cluster-randomized trial of insecticide-treated curtains for dengue vector control in Thailand","volume":"88","author":"A Lenhart","year":"2013","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"4","key":"pntd.0010135.ref015","doi-asserted-by":"crossref","first-page":"e0008097","DOI":"10.1371\/journal.pntd.0008097","article-title":"The impact of insecticide treated curtains on dengue virus transmission: A cluster randomized trial in Iquitos, Peru","volume":"14","author":"A Lenhart","year":"2020","journal-title":"PLoS neglected tropical diseases"},{"issue":"3","key":"pntd.0010135.ref016","doi-asserted-by":"crossref","first-page":"e0119373","DOI":"10.1371\/journal.pone.0119373","article-title":"No effect of insecticide treated curtain deployment on aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba","volume":"10","author":"ME Toledo","year":"2015","journal-title":"PloS one"},{"issue":"11","key":"pntd.0010135.ref017","doi-asserted-by":"crossref","first-page":"e0006031","DOI":"10.1371\/journal.pntd.0006031","article-title":"The additional benefit of residual spraying and insecticide-treated curtains for dengue control over current best practice in Cuba: Evaluation of disease incidence in a cluster randomized trial in a low burden setting with intensive routine control","volume":"11","author":"ME Toledo","year":"2017","journal-title":"PLoS neglected tropical diseases"},{"issue":"2","key":"pntd.0010135.ref018","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3201\/eid2102.140533","article-title":"Use of insecticide-treated house screens to reduce infestations of dengue virus vectors, Mexico","volume":"21","author":"P Manrique-Saide","year":"2015","journal-title":"Emerging infectious diseases"},{"issue":"3","key":"pntd.0010135.ref019","doi-asserted-by":"crossref","first-page":"e0006283","DOI":"10.1371\/journal.pntd.0006283","article-title":"House screening with insecticide-treated netting provides sustained reductions in domestic populations of Aedes aegypti in Merida, Mexico","volume":"12","author":"A Che-Mendoza","year":"2018","journal-title":"PLoS neglected tropical diseases"},{"issue":"1","key":"pntd.0010135.ref020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4269\/ajtmh.2010.09-0346","article-title":"The epidemiology of dengue in the americas over the last three decades: a worrisome reality","volume":"82","author":"JL San Martin","year":"2010","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"pntd.0010135.ref021","unstructured":"PAHO: 2007: Number of Reported Cases of Dengue & Dengue Hemorrhagic Fever (DHF), Region of the Americas (by country and subregion). Pan American Health Organization; 2008."},{"key":"pntd.0010135.ref022","unstructured":"PAHO: 2008: Number of Reported Cases of Dengue & Dengue Hemorrhagic Fever (DHF), Region of the Americas (by country and subregion). Pan American Health Organization; 2009."},{"key":"pntd.0010135.ref023","unstructured":"MPPS: Bolet\u00edn Epidemiol\u00f3gico del Ministerio del Poder Popular para la Salud. In: EPIDEMIOLOG\u00cdA, D G D. Venezuela: Ministerio del Poder Popular para la Salud; 2009."},{"key":"pntd.0010135.ref024","unstructured":"MSDS. Trujillo, Venezuela: Direcci\u00f3n Regional de Epidemiolog\u00eda y Estad\u00edstica Vital; 2005."},{"key":"pntd.0010135.ref025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ije\/28.2.319","article-title":"Simple sample size calculation for cluster-randomized trials","volume":"28","author":"RJ Hayes","year":"1999","journal-title":"International Journal of Epidemiology"},{"key":"pntd.0010135.ref026","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4269\/ajtmh.1923.s1-3.9","article-title":"Stegomyia indices and their value in yellow fever control","volume":"3","author":"ME Connor","year":"1923","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"pntd.0010135.ref027","first-page":"453","article-title":"Yellow fever in French West Africa; an aspect of mass-preventive medicine","volume":"11","author":"H. Breteau","year":"1954","journal-title":"Bulletin of the World Health Organization"},{"issue":"2","key":"pntd.0010135.ref028","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4269\/ajtmh.1997.56.159","article-title":"Pupal survey: An epidemiologically significant surveillance method for Aedes aegypti: An example using data from Trinidad","volume":"56","author":"DA Focks","year":"1997","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"issue":"1","key":"pntd.0010135.ref029","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actatropica.2005.06.020","article-title":"Building a better ovitrap for detecting Aedes aegypti oviposition","volume":"96","author":"AE Lenhart","year":"2005","journal-title":"Acta tropica"},{"issue":"S1","key":"pntd.0010135.ref030","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1179\/136485906X105516","article-title":"Use of the pupal\/demographic survey technique to identify the epidemiologically important types of containers producing Aedes aegypti (L.) in a dengue-endemic area of Venezuela","volume":"100","author":"AE Lenhart","year":"2006","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"pntd.0010135.ref031","unstructured":"WHO: Test procedures for insecticide resistance monitoring in malaria vectors, bio-efficacy and persistence of insecticides on treated surfaces. Geneva, Switzerland: World Health Organization; 1998."},{"key":"pntd.0010135.ref032","unstructured":"R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https:\/\/www.R-project.org\/"},{"key":"pntd.0010135.ref033","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511973420","volume-title":"Negative Binomial Regression","author":"J. Hilbe","year":"2011","edition":"2"},{"issue":"8703","key":"pntd.0010135.ref034","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/0140-6736(90)91515-C","article-title":"Baseline comparisons in clinical trials","volume":"335","author":"DG Altman","year":"1990","journal-title":"The Lancet"},{"key":"pntd.0010135.ref035","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/sim.4780131703","article-title":"Testing for baseline balance in clinical trials","volume":"13","author":"S. Senn","year":"1994","journal-title":"Statistics in Medicine"},{"key":"pntd.0010135.ref036","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1177\/009286159903300425","article-title":"Issues in adjusting for covariates arising postrandomization in clinical trials","volume":"33","author":"J. Rochon","year":"1999","journal-title":"Drug Information Journal"},{"issue":"1","key":"pntd.0010135.ref037","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4269\/ajtmh.13-0015","article-title":"Coverage-dependent effect of insecticide-treated curtains for dengue control in Thailand","volume":"89","author":"V Vanlerberghe","year":"2013","journal-title":"The American Journal of Tropical Medicine and Hygiene"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0010135","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T13:50:21Z","timestamp":1647438621000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010135"}},"subtitle":[],"editor":[{"given":"Guilherme S.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0010135","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]}}}