{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:35:04Z","timestamp":1785216904625,"version":"3.55.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"George Washington University\/National Cancer Institute","award":["NIH-T32CA247756"],"award-info":[{"award-number":["NIH-T32CA247756"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["NIH-R01DK113504"],"award-info":[{"award-number":["NIH-R01DK113504"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Urogenital schistosomiasis remains a major public health concern worldwide. In response to egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to date imply that the molecular mechanisms underlying pathology are not well-defined. We leveraged a mouse model of urogenital schistosomiasis to perform for the first time, proteome profiling of the early molecular events that occur in the bladder after exposure to\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>haematobium<\/jats:italic>\n                    eggs, and to elucidate the protein pathways involved in urogenital schistosomiasis-induced pathology. Purified\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>haematobium<\/jats:italic>\n                    eggs or control vehicle were microinjected into the bladder walls of mice. Mice were sacrificed seven days post-injection and bladder proteins isolated and processed for proteome profiling using mass spectrometry. We demonstrate that biological processes including carcinogenesis, immune and inflammatory responses, increased protein translation or turnover, oxidative stress responses, reduced cell adhesion and epithelial barrier integrity, and increased glucose metabolism were significantly enriched in\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>haematobium<\/jats:italic>\n                    infection.\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>haematobium<\/jats:italic>\n                    egg deposition in the bladder results in significant changes in proteins and pathways that play a role in pathology. Our findings highlight the potential bladder protein indicators for host-parasite interplay and provide new insights into the complex dynamics of pathology and characteristic bladder tissue changes in urogenital schistosomiasis. The findings will be relevant for development of improved interventions for disease control.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0010176","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:47:41Z","timestamp":1644932861000},"page":"e0010176","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-5384","authenticated-orcid":true,"given":"Derick N. M.","family":"Osakunor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K.","family":"Lamanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Dwomoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"issue":"9","key":"pntd.0010176.ref001","doi-asserted-by":"crossref","DOI":"10.5812\/ijcm.9430","article-title":"Halting Schistosoma haematobium\u2014associated bladder cancer","volume":"10","author":"MC Botelho","year":"2017","journal-title":"Int J Cancer Manag"},{"key":"pntd.0010176.ref002","unstructured":"World Health Organization. Schistosomiasis: World Health Organization (WHO); 2020 [updated 2\/03\/2020; cited 2020 09\/03]. 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