{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:57:04Z","timestamp":1787021824053,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Onchocerciasis, a neglected tropical disease of public health importance, causes chronic morbidity and severe disability that may impact on health-related quality of life (HRQoL) of the infected people. This study assessed the HRQoL and associated factors among onchocerciasis patients in southeast Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a community-based cross-sectional comparative study. Using a multistage sampling technique, 340 onchocerciasis patients were selected and matched for age and gender with the healthy population in the same neighbourhood. The respondents were interviewed using the short-form-36 (SF-36) questionnaire to determine their HRQoL. WHO Disability Assessment Schedule 2.0 tool (WHODAS 2.0) was used to assess disability in persons with onchocerciasis. Means were compared with independent student t-test while Chi-square test was used to compare proportions. Also, correlation analysis and logistic regression were used in the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significantly lower proportion of people living with onchocerciasis had a good quality of life when compared with the healthy subjects (69.4% vs 93.5%, p&lt;0.001). Also, an inverse relationship was seen between disability and quality of life in the onchocerciasis group (r = -0.647, p&lt;0.001). Predictors of poor quality of life among respondents with onchocerciasis were: respondents aged \u226548 years (AOR = 2.5, 95% CI: 1.4\u20135.0), those with some disability associated with onchocerciasis (AOR = 3.33, 95%CI: 1.4\u20135.0) and respondents who perceived themselves as a burden to people (AOR = 10, 95%CI: 2.5\u201320).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Onchocerciasis impacted negatively on HRQoL of persons with onchocerciasis when compared with the healthy population. The quality of life of persons affected with onchocerciasis reduces with increasing disability. There is the need to increase community awareness on onchocerciasis to ensure early diagnosis and prompt treatment as this will reduce disability among those affected with the disease thus enhancing their HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0010182","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T13:26:43Z","timestamp":1644413203000},"page":"e0010182","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Health-related quality of life and associated factors among Onchocerciasis patients in southeast Nigeria: A cross-sectional comparative study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-1325","authenticated-orcid":true,"given":"Adah E.","family":"Otache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-292X","authenticated-orcid":true,"given":"Ifeyinwa L.","family":"Ezenwosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-4898","authenticated-orcid":true,"given":"Edmund N.","family":"Ossai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias C.","family":"Aniwada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel A.","family":"Nwobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-0455","authenticated-orcid":true,"given":"Benjamin SC.","family":"Uzochukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"issue":"7","key":"pntd.0010182.ref001","doi-asserted-by":"crossref","first-page":"e0009604","DOI":"10.1371\/journal.pntd.0009604","article-title":"The burden of skin disease and eye disease due to onchocerciasis in countries formerly under the African Programme for Onchocerciasis Control mandate for 1990, 2020, and 2030.","volume":"15","author":"NVS Vinkeles Melchers","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0010182.ref002","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2149\/tmh.2015-S12","article-title":"Review of the Biology and Ecology of Adult Blackflies in Relation to the Transmission of Onchocerciasis in Guatemala","volume":"43","author":"H. 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