{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:52:17Z","timestamp":1785127937626,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010315","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Establishment of novel mosquito control technologies such as the use of genetically engineered insects typically involves phased testing to generate robust data-sets that support its safe and effective use as a vector control tool. In this study, we demonstrate the ability of the transgenic self-limiting OX513A <jats:italic>Aedes aegypti<\/jats:italic> strain to suppress a wild type <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> population in an outdoor containment facility in India. OX513A is a genetically engineered <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> strain with a repressible dominant self-limiting gene. When male adult OX513A mate with wild female adults, a single copy of the self-limiting gene is inherited by all the progeny, leading to death of &gt;95% of progeny during larval\/pupal development. A wild-type population of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> was established and stabilized during a 14 week period in five paired field cage units, each consisting of control and treatment cages, followed by weekly releases of OX513A male adults to suppress the target population. The successive introductions of OX513A male adults led to a consistent decline in wild type numbers eventually resulting in the elimination of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> from all treated cages within 10 to 15 weeks of release. This study demonstrates that <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> elimination may be a realistic and achievable target in relatively isolated environments.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010315","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T17:29:03Z","timestamp":1652722143000},"page":"e0010315","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2336-0469","authenticated-orcid":true,"given":"Prabhakargouda B.","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaibal Kumar","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pickl-Herk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-7667","authenticated-orcid":true,"given":"Mirel","family":"Puinean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-3707","authenticated-orcid":true,"given":"Andrew","family":"McKemey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-8480","authenticated-orcid":true,"given":"Bharat","family":"Char","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha B.","family":"Zehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish R.","family":"Barwale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"pntd.0010315.ref001","unstructured":"CBD Secretariat. 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