{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:11:21Z","timestamp":1782958281480,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010360","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000}}],"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["209387\/Z\/17\/Z"],"award-info":[{"award-number":["209387\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK-China Cooperation on Climate Change Risk Assessment","award":["PF3051_CH-WS3HBUE_YR1"],"award-info":[{"award-number":["PF3051_CH-WS3HBUE_YR1"]}]},{"name":"Study on Public Health Problems caused by Climate Change","award":["Grant No. 202046"],"award-info":[{"award-number":["Grant No. 202046"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Dengue fever has been a significant public health challenge in China. This will be particularly important in the context of global warming, frequent international travels, and urbanization with increasing city size and population movement. In order to design relevant prevention and control strategies and allocate health resources reasonably, this study evaluated the economic burden of dengue fever in China in 2019.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The economic burden of dengue fever patients was calculated from both family and the organisation perspectives. A survey was conducted among 1,027 dengue fever patients in Zhejiang, Chongqing, and Yunnan Provinces. Treatment expenses, lost working days, and insurance reimbursement expenses information were collected to estimate the total economic burden of dengue fever patients in 2019. The expenditures related to dengue fever prevention and control from government, Center for Disease Control and Prevention (CDC), communities and subdistrict offices of 30 counties (or districts) in Zhejiang Province and Chongqing City were also collected.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The direct, indirect and total economic burden for dengue fever patients in 2019 in the three Provinces were about 36,927,380.00 Chinese Yuan (CNY), 10,579,572.00 CNY and 46,805,064.00 CNY, respectively. The costs for prevention and control of dengue fever for the counties (or districts) without cases, counties (or districts) with imported cases, and counties (or districts) with local cases are 205,800.00 CNY, 731,180.00 CNY and 6,934,378.00 CNY, respectively. The total investment of dengue fever prevention and control in the 30 counties in China in 2019 was approximately 3,166,660,240.00 CNY.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The economic burden of dengue fever patients is relatively high, and medical insurance coverage should be increased to lighten patients\u2019 direct medical economic burden. At the same time, the results suggests that China should increase funding for primary health service institutions to prevent dengue fever transmission.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010360","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T17:46:39Z","timestamp":1653068799000},"page":"e0010360","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Economic burden of dengue fever in China: A retrospective research study"],"prefix":"10.1371","volume":"16","author":[{"given":"Meng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotian","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenge","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengqing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-7988","authenticated-orcid":true,"given":"Qiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"issue":"6","key":"pntd.0010360.ref001","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1473-3099(16)00076-1","article-title":"The elusive global burden of dengue[J]","volume":"16","author":"A Wilder-Smith","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"pntd.0010360.ref002","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1089\/vim.2012.0039","article-title":"Inapparent infection during an outbreak of dengue fever in Southeastern China. [J]","volume":"25","author":"J Sun","year":"2012","journal-title":"Viral Immunology"},{"issue":"7446","key":"pntd.0010360.ref003","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue[J]","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"issue":"4","key":"pntd.0010360.ref004","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00006454-199204000-00010","article-title":"Dengue and dengue hemorrhagic fever. 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Liao","year":"2018","journal-title":"China Medicine and Pharmacy"},{"key":"pntd.0010360.ref020","article-title":"Epidemiological characteristics, sequelae and disease burden of Japanese Encephalitis in Gansu Province [J]","author":"XX Wang","year":"2009","journal-title":"The Chinese Center for Disease Control and Prevention"},{"issue":"04","key":"pntd.0010360.ref021","first-page":"36","article-title":"Epidemiological investigation and economic burden analysis of an outbreak of scrub typhus [J]","author":"DF Ren","year":"2015","journal-title":"Jiangsu Journal of Preventive Medicine"},{"issue":"4","key":"pntd.0010360.ref022","first-page":"385","article-title":"Study on the Economic Burden of Dengue Fever Disease in Ningbo City, Zhejiang Province[J]","volume":"31","author":"Y Chen","year":"2020","journal-title":"China J Vector Biol Control"},{"issue":"10","key":"pntd.0010360.ref023","first-page":"e6037","article-title":"A multi-country study of the economic burden of dengue fever: Vietnam, Thailand, and Colombia[J]","volume":"11","author":"S Lee J","year":"2017","journal-title":"PLoS Negl Trop Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0010360","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T17:48:02Z","timestamp":1654192082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010360"}},"subtitle":[],"editor":[{"given":"Elvina","family":"Viennet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0010360","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0010360","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]}}}