{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:18:31Z","timestamp":1776478711356,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010369","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000}}],"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China","award":["MOHW104-CDC-315-000115"],"award-info":[{"award-number":["MOHW104-CDC-315-000115"]}]},{"name":"Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China","award":["MOHW105-CDC-315-122110"],"award-info":[{"award-number":["MOHW105-CDC-315-122110"]}]},{"name":"Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China","award":["MOHW106-CDC-C-315-113112"],"award-info":[{"award-number":["MOHW106-CDC-C-315-113112"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Scrub typhus is the most common endemic vector-borne disease in Taiwan. We identified a total of 4,857 laboratory-confirmed cases during 2006\u20132016 with hyperendemic foci on offshore islands, including Penghu (778 cases, 16.0%) and Kinmen (716 cases, 14.7%), and eastern Taiwan, including Taitung (628 cases, 12.9%) and Hualien (508 cases, 10.5%). Scrub typhus cases occur year-round throughout Taiwan, with a summer peak in June and July. A total of 545 <jats:italic>O<\/jats:italic>. <jats:italic>tsutsugamushi<\/jats:italic> isolates were successfully obtained from patients infected in diverse geographic areas, including Taiwan and three offshore islands, and the complete open reading frame of the 56 kDa type-specific antigen gene (<jats:italic>tsa56<\/jats:italic>) sequence of these isolates was examined. High phylogenetic diversity was found in these isolates, which could be grouped into 36 distinct sequence types. Most isolates belonged to the Karp (49.9%; 272\/545), followed by the TW-22 (17.8%; 97\/454) and Kawasaki (14.7%; 80\/545) genotypes. In conclusion, our data indicate the widespread presence of <jats:italic>tsa56<\/jats:italic> genotypes closely related to Thailand and Korean strains and the presence of the unique endemic strains TW-12, TW-22, TW-29, and TW-36 in Taiwan.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010369","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T18:03:05Z","timestamp":1651255385000},"page":"e0010369","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular epidemiology of scrub typhus in Taiwan during 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