{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:33:38Z","timestamp":1788885218903,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010381","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000683","name":"Royal Society of Tropical Medicine and Hygiene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Despite the ongoing intervention for schistosomiasis control among school-age children in the Lindi region of Tanzania, urogenital schistosomiasis continues to be a public health problem, presumably because other at-risk populations are not covered in praziquantel deworming campaigns. Evidence shows that under-fives become infected in their early life hence the need to understand the disease profile and the risk factors for exposure to infection so as to plan effective control strategies in this group. This study examined the prevalence and risk factors of urogenital schistosomiasis among under-fives in the Mtama district, Lindi region of Tanzania.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology\/Principal findings<\/jats:title>\n<jats:p>A quantitative community-based cross-sectional study was carried out among 770 participants (385 under-fives and their 385 parents\/guardians) in the Mtama district to investigate the burden and the risk factors associated with <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> infection. A single urine specimen was collected from the under-fives and tested for macro and microhaematuria, presence of <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> ova, and intensity of infection. A structured questionnaire gathered on risk factors for <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> exposure in under-fives from their parents\/guardians. Data analysis was performed using descriptive statistics, chi-square test, and logistic regression.<\/jats:p>\n<jats:p>Prevalence of <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> ova was 16.9%, and that of macro and microhaematuria was 6% and 17.9%, respectively. Of the 65 positive under-fives, 49 (75.4%) 95% CI 65.4\u201386.3 had a light infection intensity, and 16 (24.6%) 95% CI 13.7\u201335.5 had a heavy infection intensity. Among the assessed risk factors, the parents\/guardians habit of visiting water bodies for domestic routines (AOR: 1.44, 95% CI: 1.13\u20131.74), especially the river (AOR: 6.00, 95% CI: 1.20\u201335.12), was found to be a significant risk factor for infection of <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> in under-fives.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusion\/Significance<\/jats:title>\n<jats:p>A moderate prevalence of <jats:italic>S<\/jats:italic>. <jats:italic>haematobium<\/jats:italic> was found among the under-fives conceivably with adverse health events. The infected under-fives could be a source of continuity for transmission in the community. An intervention that covers this group is necessary and should be complemented with regular screening, health education campaigns, and an adequate supply of safe water.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010381","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T17:35:52Z","timestamp":1650476152000},"page":"e0010381","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence and risk factors of urogenital schistosomiasis among under-fives in Mtama District in the Lindi region of Tanzania"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-3057","authenticated-orcid":true,"given":"Vivian","family":"Mushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Zacharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marycelina","family":"Mubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donath","family":"Tarimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"pntd.0010381.ref001","unstructured":"World Health Organization. Schistosomiasis 2019. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis (Accessed September 23, 2021)."},{"issue":"12","key":"pntd.0010381.ref002","doi-asserted-by":"crossref","first-page":"e3296","DOI":"10.1371\/journal.pntd.0003296","article-title":"The relationship between water, sanitation and schistosomiasis: a systematic review and meta-analysis","volume":"8","author":"JE Grimes","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pntd.0010381.ref003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4172\/2329-9088.1000135","article-title":"Bilharzia: Pathology, Diagnosis, Management and Control","volume":"1","author":"DU Olveda","year":"2013","journal-title":"Trop Med Surg"},{"issue":"9936","key":"pntd.0010381.ref004","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"DG Colley","year":"2014","journal-title":"Lancet"},{"key":"pntd.0010381.ref005","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13071-019-3667-5","article-title":"Urogenital schistosomiasis and risk factors of infection in mothers and preschool children in an endemic district in Zimbabwe","volume":"12","author":"M.J Mutsaka-Makuvaza","year":"2019","journal-title":"Parasites Vectors"},{"key":"pntd.0010381.ref006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-3305-4-21","article-title":"Urinary schistosomiasis among preschool-aged children in Sahelian rural communities in Mali","volume":"4","author":"A Dabo","year":"2011","journal-title":"Parasit Vectors"},{"issue":"7","key":"pntd.0010381.ref007","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1017\/S0031182012000029","article-title":"Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control","volume":"139","author":"UF Ekpo","year":"2012","journal-title":"Parasitology"},{"issue":"2","key":"pntd.0010381.ref008","doi-asserted-by":"crossref","first-page":"e0006144","DOI":"10.1371\/journal.pntd.0006144","article-title":"Paediatric schistosomiasis: What we know and what we need to know","volume":"12","author":"DNM Osakunor","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0010381.ref009","doi-asserted-by":"crossref","first-page":"e0007808","DOI":"10.1371\/journal.pntd.0007808","article-title":"Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis","volume":"13","author":"DM Cribb","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0010381.ref010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40249-017-0300-8","article-title":"Putting the treatment of paediatric schistosomiasis into context","volume":"6","author":"T Mduluza","year":"2017","journal-title":"Infect Dis Poverty"},{"key":"pntd.0010381.ref011","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1756-3305-5-274","article-title":"Epidemiology and control of human schistosomiasis in Tanzania","volume":"5","author":"HD Mazigo","year":"2012","journal-title":"Parasit Vectors"},{"issue":"7","key":"pntd.0010381.ref012","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pntd.0010381.ref013","first-page":"230","article-title":"Prevalence of urogenital Schistosomiasis and risk factors for transmission among primary school children in an endemic urban area of Kinondoni municipality in Dar es Salaam, Tanzania","volume":"3","author":"Y Yangaza","year":"2022","journal-title":"Microbes and Infectious Diseases"},{"issue":"3","key":"pntd.0010381.ref014","doi-asserted-by":"crossref","first-page":"162","DOI":"10.12980\/apjtd.7.2017D6-359","article-title":"Urinary schistosomiasis among preschool-age children in an endemic area of Kinondoni municipality, Dar es Salaam, Tanzania","volume":"7","author":"S B","year":"2017","journal-title":"Asian Pac J Trop Dis"},{"key":"pntd.0010381.ref015","unstructured":"World Health Organization. OSM-Distribution of Schistosomiasis in Southern- Tanzania. 1987. http:\/\/158.232.12.119\/schistosomiasis\/epidemiology\/en\/tanzania.pdf (Accessed September 29, 2021)."},{"key":"pntd.0010381.ref016","unstructured":"Ministry of Health, Community Development, Gender Elderly, and Children. National Sanitation Campaign Report. 2018."},{"key":"pntd.0010381.ref017","unstructured":"Ministry of Water. Report on a water project in South-eastern Tanzania. 2010."},{"issue":"1","key":"pntd.0010381.ref018","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41598-020-80317-x","article-title":"Prevalence, infection intensity and geographical distribution of schistosomiasis among pre-school and school aged children in villages surrounding Lake Nyasa, Tanzania","volume":"11","author":"HD Mazigo","year":"2021","journal-title":"Sci Rep"},{"key":"pntd.0010381.ref019","unstructured":"National Bureau of Statistics. The United Republic of Tanzania 2012 population and housing census distributed by administrative areas. Ministry of Finance. 2013."},{"issue":"2","key":"pntd.0010381.ref020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.24248\/eahrj.v2i2.590","article-title":"Demographic Factors Driving Schistosomiasis and Soil-Transmitted Helminthiases in Milola Ward, Lindi District, Tanzania: A Useful Guide for Launching Intervention Programmes","volume":"2","author":"J. Bakuza","year":"2018","journal-title":"East African Health Res J"},{"key":"pntd.0010381.ref021","first-page":"744","article-title":"Biostatistics\u2014A Foundations for Analysis in the Health Sciences. Wiley & Sons, New York\u2014Chichester\u2014Brisbane\u2014Toronto\u2014Singapore, 6th ed. 1995","volume":"37","author":"W. Daniel","journal-title":"Biometrical J."},{"key":"pntd.0010381.ref022","doi-asserted-by":"crossref","unstructured":"Cheesbrough M. District Laboratory Practice in Tropical Countries, Part 2 Second Edition. Cambridge University Press, 2006.","DOI":"10.1017\/CBO9780511543470"},{"key":"pntd.0010381.ref023","unstructured":"World Health Organization. Prevention and control of schistosomiasis and soil-transmittedhelminthiasis: report of a WHO expert committee. Geneva\u2014Switzerland: 2002. https:\/\/apps.who.int\/iris\/handle\/10665\/42588"},{"issue":"1","key":"pntd.0010381.ref024","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4314\/mmj.v28i1.3","article-title":"Urinary schistosomiasis among preschool children in Malengachanzi, Nkhotakota District, Malawi: Prevalence and risk factors","volume":"28","author":"VB Moyo","year":"2016","journal-title":"Malawi Med J"},{"issue":"11","key":"pntd.0010381.ref025","doi-asserted-by":"crossref","first-page":"e0009083","DOI":"10.1371\/journal.pntd.0009083","article-title":"Gender-related differences in prevalence, intensity and associated risk factors of Schistosoma infections in Africa: A systematic review and meta-analysis","volume":"15","author":"DV Ayabina","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0010381.ref026","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1186\/s12889-019-7041-5","article-title":"Community knowledge, perceptions and water contact practices associated with transmission of urinary schistosomiasis in an endemic region: a qualitative cross-sectional study","volume":"19","author":"T Angelo","year":"2019","journal-title":"BMC Public Health"},{"key":"pntd.0010381.ref027","first-page":"161","article-title":"Knowledge, attitudes and practices regarding urinary schistosomiasis among adults in the Ekombe Bonji Health Area, Cameroon","volume":"29","author":"LN Folefac","year":"2018","journal-title":"Pan Afr Med J"},{"issue":"1","key":"pntd.0010381.ref028","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12879-017-2923-6","article-title":"Knowledge, attitudes and practices on Schistosomiasis in sub-Saharan Africa: a systematic review","volume":"18","author":"H Sacolo","year":"2018","journal-title":"BMC Infect Dis"},{"issue":"4","key":"pntd.0010381.ref029","doi-asserted-by":"crossref","first-page":"e2651","DOI":"10.1371\/journal.pntd.0002651","article-title":"Water, Sanitation, and Hygiene (WASH): a critical component for sustainable soil-transmitted helminth and schistosomiasis control","volume":"8","author":"SJ Campbell","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0010381.ref030","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13071-015-0766-9","article-title":"The roles of water, sanitation and hygiene in reducing schistosomiasis: a review","volume":"8","author":"JE Grimes","year":"2015","journal-title":"Parasit Vectors"},{"key":"pntd.0010381.ref031","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1756-3305-3-58","article-title":"Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria","volume":"3","author":"UF Ekpo","year":"2010","journal-title":"Parasit Vectors"},{"issue":"1","key":"pntd.0010381.ref032","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S1995-7645(13)60188-1","article-title":"Prevalence, intensity of infection and risk factors of urinary schistosomiasis in pre-school and school aged children in Guma Local Government Area","volume":"7","author":"EU Amuta","year":"2014","journal-title":"Nigeria. 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