{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:51:24Z","timestamp":1792702284641,"version":"4.5.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses is a frequently reported acute hemorrhagic fever in South Korea. These viruses are transmitted by various rodent species such as <jats:italic>Apodemus agrarius<\/jats:italic>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology\/Principal findings<\/jats:title>\n<jats:p>To investigate hantavirus infection and seroprevalence in rodents, wild rodents were captured from two districts in the suburbs of Gwangju Metropolitan City from January 2016 to December 2018. Nested reverse-transcription polymerase chain reaction (RT-PCR) targeting the hantavirus-specific L segment and indirect immunofluorescence antibody (IFA) assay using Hantaan virus antigen slides were performed. A total of 585 wild rodents were captured\u2014512 <jats:italic>A<\/jats:italic>. <jats:italic>agrarius<\/jats:italic>, 49 <jats:italic>Crocidura lasiura<\/jats:italic>, and 24 <jats:italic>Myodes regulus<\/jats:italic>. Nested RT-PCR was performed to examine the rate of hantavirus infection in wild rodents, and 1.88% (11\/585) of all rodents, 1.17% (6\/512) of <jats:italic>A<\/jats:italic>. <jats:italic>agrarius<\/jats:italic>, 6.12% (3\/49) of <jats:italic>C<\/jats:italic>. <jats:italic>lasiura<\/jats:italic>, and 8.33% (2\/24) of <jats:italic>M<\/jats:italic>. <jats:italic>regulus<\/jats:italic> tested positive. The nucleotide sequence analysis of the eleven PCR-positive products revealed that six PCR products showed over 85% sequence similarity with the Jeju virus, four showed over 99.7% similarity with the Hantaan virus, and one showed over 95.3% homology with the Imjin virus. Moreover, IgG antibodies against the Hantaan virus were detected in 6.15% (36\/585) of all rodents, 6.8% (35\/512) of <jats:italic>A<\/jats:italic>. <jats:italic>agrarius<\/jats:italic>, and 4.17% (1\/24) of <jats:italic>M<\/jats:italic>. <jats:italic>regulus<\/jats:italic>. IgG antibodies were not detected in <jats:italic>C<\/jats:italic>. <jats:italic>lasiura<\/jats:italic>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions\/Significance<\/jats:title>\n<jats:p>Hantaviruses were detected in all three wild rodent species of <jats:italic>A<\/jats:italic>. <jats:italic>agrarius<\/jats:italic>, <jats:italic>C<\/jats:italic>. <jats:italic>lasiura<\/jats:italic>, and <jats:italic>M<\/jats:italic>. <jats:italic>regulus<\/jats:italic> captured in the suburbs of Gwangju Metropolitan City, South Korea, and it was demonstrated that they were various strains of hantaviruses such as the Hantaan, Jeju, and Imjin viruses.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010526","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:24:02Z","timestamp":1656005042000},"page":"e0010526","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Emerging hantavirus infection in wild rodents captured in suburbs of Gwangju Metropolitan City, South Korea"],"prefix":"10.1371","volume":"16","author":[{"given":"Mi hee","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon-Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-0922","authenticated-orcid":true,"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Wook","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Keun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"issue":"2","key":"pntd.0010526.ref001","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1128\/CMR.00062-09","article-title":"A global perspective on hantavirus ecology, epidemiology, and disease","volume":"23","author":"CB Jonsson","year":"2010","journal-title":"Clin Microbiol Rev."},{"issue":"9","key":"pntd.0010526.ref002","doi-asserted-by":"crossref","DOI":"10.3390\/v11090788","article-title":"Hantaviridae: Current Classification and Future Perspectives","volume":"11","author":"L Laenen","year":"2019","journal-title":"Viruses"},{"issue":"1","key":"pntd.0010526.ref003","first-page":"30","article-title":"Hantaviruses. a short review","volume":"127","author":"JA Lednicky","year":"2003","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"pntd.0010526.ref004","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3947\/ic.2019.51.4.405","article-title":"Hemorrhagic Fever with Renal Syndrome","volume":"51","author":"JY Noh","year":"2019","journal-title":"Infect Chemother."},{"key":"pntd.0010526.ref005","first-page":"1","article-title":"Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture","volume":"6","author":"H Jiang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"pntd.0010526.ref006","first-page":"1","article-title":"Hantaviruses: history and overview","volume":"256","author":"KM Johnson","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"pntd.0010526.ref007","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3347\/kjp.2016.54.3.307","article-title":"Seroepidemiological Survey of Zoonotic Diseases in Small Mammals with PCR Detection of Orientia tsutsugamushi in Chiggers, Gwangju, Korea","volume":"54","author":"JW Park","year":"2016","journal-title":"Korean J Parasitol"},{"key":"pntd.0010526.ref008","volume-title":"Rodents: training and information guide","author":"JE Brooks","year":"1987"},{"issue":"5","key":"pntd.0010526.ref009","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3201\/eid1205.051487","article-title":"Hantavirus in African wood mouse, Guinea","volume":"12","author":"B Klempa","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"pntd.0010526.ref010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s13365-018-0708-3","article-title":"Molecular detection of viruses causing hemorrhagic fevers in rodents in the south-west of Korea","volume":"25","author":"S Jalal","year":"2019","journal-title":"J Neurovirol"},{"issue":"1","key":"pntd.0010526.ref011","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12879-019-3794-9","article-title":"Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001\u20132017","volume":"19","author":"Y. Park","year":"2019","journal-title":"BMC Infect Dis."},{"issue":"3","key":"pntd.0010526.ref012","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4167\/jbv.2006.36.3.205","article-title":"Epidemiological Survey of Hantaan Virus Infection of Wild Rodents Trapped in Jeollanam-do, 2003~2004","volume":"36","author":"HJ Song","year":"2006","journal-title":"J Bacteriol Virol"},{"issue":"1","key":"pntd.0010526.ref013","first-page":"83","article-title":"Serologic and Genetic Characterization of Hantavirus from Apodemus Mice Captured in Kyonggi-do and Gangwon-do, 2001","volume":"32","author":"JH Nam","year":"2002","journal-title":"J Bacteriol Virol"},{"issue":"1","key":"pntd.0010526.ref014","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1948-7134.2012.00205.x","article-title":"Seroprevalence of hantaviruses in small wild mammals trapped in South Korea from 2005 to 2010","volume":"37","author":"MY Lim","year":"2012","journal-title":"J Vector Ecol."},{"issue":"2","key":"pntd.0010526.ref015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.7589\/0090-3558-47.2.427","article-title":"Prevalence of hantavirus infection in wild rodents from five provinces in Korea, 2007","volume":"47","author":"J Ryou","year":"2011","journal-title":"J Wildl Dis"},{"issue":"12","key":"pntd.0010526.ref016","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1128\/JVI.00371-09","article-title":"Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura)","volume":"83","author":"JW Song","year":"2009","journal-title":"J Virol"},{"key":"pntd.0010526.ref017","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1743-422X-8-56","article-title":"Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004\u20132010","volume":"8","author":"SH Gu","year":"2011","journal-title":"Virol J."},{"issue":"2","key":"pntd.0010526.ref018","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virol.2011.11.013","article-title":"Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea","volume":"424","author":"S Arai","year":"2012","journal-title":"Virology"},{"issue":"2","key":"pntd.0010526.ref019","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3947\/ic.2018.50.2.120","article-title":"Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea","volume":"50","author":"YH Park","year":"2018","journal-title":"Infect Chemother."}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:24:21Z","timestamp":1656005061000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010526"}},"subtitle":[],"editor":[{"given":"Wen-Ping","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0010526","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]}}}