{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:06:08Z","timestamp":1768349168881,"version":"3.49.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The prevalence of <jats:italic>Strongyloides stercoralis<\/jats:italic> infection is estimated to be 30\u2013100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection in a South Indian adult population.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>To this end, we performed community-based screening of 2351 individuals (aged 18\u201365) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> was performed using the NIE ELISA.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Our data shows a seroprevalence of 33% (768\/2351) for <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection which had a higher prevalence among males 36% (386\/1069) than among females 29.8% (382\/1282). Adults aged \u226555 (aOR = 1.65, 95% CI: 1.25\u20132.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19\u20131.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11\u20131.53) were significantly associated with <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82\u20131.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83\u20131.69) was not associated with <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> seropositivity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study provides evidence for a very high baseline prevalence of <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection in South Indian communities and this information could provide realistic and concrete planning of control measures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010561","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T17:30:09Z","timestamp":1658338209000},"page":"e0010561","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Seroprevalence of Strongyloides stercoralis infection 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