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Fifteen patients had cryptogenic hepatitis (CH) and 35 had alcoholic, drug-induced or autoimmune liver disease. DNA was extracted from whole blood and liquid culture samples, isolates, and skin fragments. Thirteen of the 50 patients (26%) had <jats:italic>Bartonella henselae<\/jats:italic> DNA detection in their blood (9\/50) and\/or skin (5\/50) samples. Colonies were isolated in 3\/50 (6%) and infection was detected in 7\/50 (14%) of the 50 patients. <jats:italic>B<\/jats:italic>. <jats:italic>henselae-<\/jats:italic>DNA detection was more prevalent in patients with CH than in other patients (<jats:italic>p<\/jats:italic> = 0.040). Of 39 patients followed-up for at least two years, a higher mortality rate was observed among patients with CH infected with <jats:italic>B<\/jats:italic>. <jats:italic>henselae<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.039).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions\/Significance<\/jats:title>\n<jats:p>Further studies assessing the role of <jats:italic>B<\/jats:italic>. <jats:italic>henselae<\/jats:italic> infection in the pathogenesis of hepatitis patients must be urgently conducted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010603","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T17:30:56Z","timestamp":1658165456000},"page":"e0010603","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryptogenic hepatitis patients have a higher Bartonella sp.-DNA detection in blood and skin samples than patients with 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