{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:52:45Z","timestamp":1790761965010,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010618","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102421"],"award-info":[{"award-number":["82102421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["lzujbky-2020-50"],"award-info":[{"award-number":["lzujbky-2020-50"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu","doi-asserted-by":"crossref","award":["20JR10RA636"],"award-info":[{"award-number":["20JR10RA636"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>2-Deoxy-D-glucose (2-DG) is a glucose analog used as a promising anticancer agent. It exerts its effects by inhibiting the glycolytic energy metabolism to deplete cells of energy. The larval stage of <jats:italic>Echinococcus<\/jats:italic> relies on glycolysis for energy production. Therefore, in this study, we investigated the <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> efficacy of 2-DG against the larval stage of <jats:italic>Echinococcus granulosus<\/jats:italic> and <jats:italic>E<\/jats:italic>. <jats:italic>multilocularis<\/jats:italic>. 2-DG exhibited significant time- and dose-dependent effects against <jats:italic>in vitro<\/jats:italic> cultured <jats:italic>E<\/jats:italic>. <jats:italic>granulosus<\/jats:italic> protoscoleces and <jats:italic>E<\/jats:italic>. <jats:italic>multilocularis<\/jats:italic> metacestodes. A daily oral administration of 500 mg\/kg 2-DG in <jats:italic>E<\/jats:italic>. <jats:italic>multilocularis<\/jats:italic>-infected mice effectively reduced the weight of metacestodes. Notably, the combination treatment, either 2-DG (500 mg\/kg\/day) + albendazole (ABZ) (200 mg\/kg\/day) or 2-DG (500 mg\/kg\/day) + half-dose of ABZ (100 mg\/kg\/day), exhibited a potent therapeutic effect against <jats:italic>E<\/jats:italic>. <jats:italic>multilocularis<\/jats:italic>, significantly promoting the reduction of metacestodes weight compared with the administration of 2-DG or ABZ alone. Furthermore, the combination significantly promoted apoptosis of the cells of metacestodes and inhibited glycolysis in metacestodes, compared with the administration of 2-DG or ABZ alone. In conclusion, 2-DG exerts an effective activity against the larval stage of <jats:italic>Echinococcus<\/jats:italic>. Thus, it may be a promising anti-<jats:italic>Echinococcus<\/jats:italic> drug, and its combination with ABZ may provide a new strategy for the treatment of echinococcosis in humans.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010618","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T17:33:11Z","timestamp":1658165591000},"page":"e0010618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["2-Deoxy-D-glucose and combined 2-Deoxy-D-glucose\/albendazole exhibit therapeutic efficacy against Echinococcus granulosus protoscoleces and experimental alveolar 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