{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:37:55Z","timestamp":1780601875470,"version":"3.54.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271865"],"award-info":[{"award-number":["81271865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Project of Anhui Province of China","award":["KJ2019A0223"],"award-info":[{"award-number":["KJ2019A0223"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Schistosomiasis is a serious and widespread parasitic disease caused by infection with\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    . Because the parasite\u2019s eggs are primarily responsible for schistosomiasis dissemination and pathogenesis, inhibiting egg production is a potential approach to control the spread and severity of the disease. The bromodomain and extra-terminal (BET) proteins represent promising targets for the development of epigenetic drugs against\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    . JQ-1 is a selective inhibitor of the BET protein family. In the present study, JQ-1 was applied to\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    in vitro. By using laser confocal scanning microscopy and EdU incorporation assays, we showed that application of JQ-1 to worms in vitro affected egg laying and the development of both the male and female reproductive systems. JQ-1 also inhibited the expression of the reproductive-related genes\n                    <jats:italic>SjPlk1<\/jats:italic>\n                    and\n                    <jats:italic>SjNanos1<\/jats:italic>\n                    in\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    . Mice infected with\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    were treated with JQ-1 during egg granuloma formation. JQ-1 treatment significantly reduced the size of the liver granulomas and levels of serum alanine aminotransferase and aspartate aminotransferase in mice and suppressed both egg laying and the development of male and female\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    reproductive systems in vivo. Moreover, the mRNA expression levels of some proinflammatory cytokines were decreased in the parasites. Our findings suggest that JQ-1 treatment attenuates\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    egg\u2013induced hepatic granuloma due at least in part to suppressing the development of the reproductive system and egg production of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>japonicum<\/jats:italic>\n                    . These findings further suggest that JQ-1 or other BET inhibitors warrant additional study as a new approach for the treatment or prevention of schistosomiasis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0010661","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T13:37:51Z","timestamp":1660052271000},"page":"e0010661","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum"],"prefix":"10.1371","volume":"16","author":[{"given":"Jiaming","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weice","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-8782","authenticated-orcid":true,"given":"Miao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"pntd.0010661.ref001","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-030-18616-6_3","article-title":"Schistosomiasis","volume":"1154","author":"PT LoVerde","year":"2019","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"pntd.0010661.ref002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis.","volume":"4","author":"DP McManus","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"9936","key":"pntd.0010661.ref003","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"DG Colley","year":"2014","journal-title":"Lancet"},{"issue":"8","key":"pntd.0010661.ref004","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1371\/journal.pntd.0000504","article-title":"Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni","volume":"3","author":"SD Melman","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pntd.0010661.ref005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exppara.2011.03.004","article-title":"Pharmacology and potential physiological significance of schistosome multidrug resistance transporters","volume":"132","author":"RS Kasinathan","year":"2012","journal-title":"Exp Parasitol"},{"issue":"11","key":"pntd.0010661.ref006","doi-asserted-by":"crossref","first-page":"E1849","DOI":"10.3390\/ijms17111849","article-title":"The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.","volume":"17","author":"Y. 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