{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:06:27Z","timestamp":1767179187904,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010690","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000}}],"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI109776"],"award-info":[{"award-number":["U19 AI109776"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"\n Background<\/jats:title>\n \n The piglet is the only model to investigate the immunogenic relationship between\n Cryptosporidium hominis<\/jats:italic>\n and\n C<\/jats:italic>\n .\n parvum<\/jats:italic>\n , the species responsible for diarrhea in humans. Despite being indistinguishable antigenically, and high genetic homology between them, they are only moderately cross protective after an\n active<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Methodology\/Principal findings<\/jats:title>\n \n Here we examined the degree of\n passive<\/jats:italic>\n protection conferred to piglets suckling sows immunized during pregnancy with\n C<\/jats:italic>\n .\n parvum<\/jats:italic>\n . After birth suckling piglets were challenged orally with either\n C<\/jats:italic>\n .\n parvum<\/jats:italic>\n or\n C<\/jats:italic>\n .\n hominis<\/jats:italic>\n at age 5 days. Animals challenged with\n C<\/jats:italic>\n .\n parvum<\/jats:italic>\n had significant reduction of infection rate, while piglets challenged with\n C<\/jats:italic>\n .\n hominis<\/jats:italic>\n showed no reduction despite high\n C<\/jats:italic>\n .\n parvum<\/jats:italic>\n serum and colostrum IgG and IgA antibody.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\/Significance<\/jats:title>\n We add these data to earlier studies where we described that infection derived immunity provides partial cross-protection. Together, it appears that for full protection, vaccines against human cryptosporidiosis must contain antigenic elements derived from both species.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pntd.0010690","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T13:42:55Z","timestamp":1659102175000},"page":"e0010690","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis"],"prefix":"10.1371","volume":"16","author":[{"given":"Abhineet","family":"Sheoran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby 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