{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:05:56Z","timestamp":1778238356540,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1082127"],"award-info":[{"award-number":["1082127"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Biological control of mosquito vectors using the endosymbiotic bacteria\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    is an emerging strategy for the management of human arboviral diseases. We recently described the development of a strain of\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    infected with the\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    strain\n                    <jats:italic>w<\/jats:italic>\n                    AlbB (referred to as the\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 strain) through simple backcrossing of wild type Australian mosquitoes with a\n                    <jats:italic>w<\/jats:italic>\n                    AlbB infected\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    strain from the USA. Field releases of male\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 mosquitoes resulted in the successful suppression of wild populations of mosquitoes in the trial sites by exploiting the strain\u2019s\n                    <jats:italic>Wolbachia-<\/jats:italic>\n                    induced cytoplasmic incompatibility. We now demonstrate that the strain is resistant to infection by dengue and Zika viruses and is genetically similar to endemic Queensland populations. There was a fourfold reduction in the proportion of\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 mosquitoes that became infected following a blood meal containing dengue 2 virus (16.7%) compared to wild type mosquitoes (69.2%) and a 6\u20137 fold reduction in the proportion of\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 mosquitoes producing virus in saliva following a blood meal containing an epidemic strain of Zika virus (8.7% in comparison to 58.3% in wild type mosquitoes). Restriction-site Associated DNA (RAD) sequencing revealed that\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 mosquitoes have &gt; 98% Australian ancestry, confirming the successful introduction of the\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2 infection into the Australian genomic background through backcrossing. Genotypic and phenotypic analyses showed the\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2-F4 strain retains the insecticide susceptible phenotype and genotype of native Australian mosquitoes. We demonstrate that the\n                    <jats:italic>Wolbachia w<\/jats:italic>\n                    AlbB2-F4, in addition to being suitable for population suppression programs, can also be effective in population replacement programs given its inhibition of virus infection in mosquitoes. The ease at which a target mosquito population can be transfected with\n                    <jats:italic>w<\/jats:italic>\n                    AlbB2, while retaining the genotypes and phenotypes of the target population, shows the utility of this strain for controlling the\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    mosquitoes and the pathogens they transmit.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0010786","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T13:47:53Z","timestamp":1665668873000},"page":"e0010786","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-9850","authenticated-orcid":true,"given":"Leon E.","family":"Hugo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Ra\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Maynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Liddington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callum J. E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisa Suraj","family":"Nath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clay","family":"Winterford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M. C. Randika","family":"Wimalasiri-Yapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel W.","family":"Beebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-0390","authenticated-orcid":true,"given":"Gregor J.","family":"Devine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"issue":"3","key":"pntd.0010786.ref001","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S1473-3099(16)30518-7","article-title":"Epidemic arboviral diseases: priorities for research and public health","volume":"17","author":"A Wilder-Smith","year":"2017","journal-title":"Lancet Infect 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