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Both\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    and\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>ovale<\/jats:italic>\n                    are endemic to Mali and cause clinical malaria, with\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    or\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>ovale<\/jats:italic>\n                    , and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by species. Additionally, we characterized DNA polymorphisms of the parasites directly from the RNA-seq reads and found comparable levels of genetic diversity in both species, despite dramatic differences in prevalence. Our results provide unique insights into host-pathogen interactions during malaria infections and their variations according to the infecting\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species, which will be critical to develop better elimination strategies against all human\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0010802","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T13:39:46Z","timestamp":1674653986000},"page":"e0010802","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-7667","authenticated-orcid":true,"given":"Kieran","family":"Tebben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salif","family":"Yirampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drissa","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye K.","family":"Kon\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Laurens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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