{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:10:12Z","timestamp":1792098612798,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010818","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000}}],"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM122077"],"award-info":[{"award-number":["R01GM122077"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["2019 Collaborative Research Travel Grant"],"award-info":[{"award-number":["2019 Collaborative Research Travel Grant"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    In models of mosquito\u2013borne transmission, the mosquito biting rate is an influential parameter, and understanding the heterogeneity of the process of biting is important, as biting is usually assumed to be relatively homogeneous across individuals, with time\u2013between\u2013bites described by an exponentially distributed process. However, these assumptions have not been addressed through laboratory experimentation. We experimentally investigated the daily biting habits of\n                    <jats:italic>Ae<\/jats:italic>\n                    .\n                    <jats:italic>aegypti<\/jats:italic>\n                    at three temperatures (24\u00b0C, 28\u00b0C, and 32\u00b0C) and determined that there was individual heterogeneity in biting habits (number of bites, timing of bites, etc.). We further explored the consequences of biting heterogeneity using an individual\u2013based model designed to examine whether a particular biting profile determines whether a mosquito is more or less likely to 1) become exposed given a single index case of dengue (DENV) and 2) transmit to a susceptible human individual. Our experimental results indicate that there is heterogeneity among individuals and among temperature treatments. We further show that this results in altered probabilities of transmission of DENV to and from individual mosquitoes based on biting profiles. While current model representation of biting may work under some conditions, it might not uniformly be the best fit for this process. Our data also confirm that biting is a non\u2013monotonic process with temperatures around 28\u00b0C being optimum.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0010818","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T13:33:12Z","timestamp":1664890392000},"page":"e0010818","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["How do i bite thee? let me count the ways: Exploring the implications of individual biting habits of Aedes aegypti for dengue transmission"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-1131","authenticated-orcid":true,"given":"Rebecca C.","family":"Christofferson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-9797","authenticated-orcid":true,"given":"Helen J.","family":"Wearing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Salje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tran-Kiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-4549","authenticated-orcid":true,"given":"Simon","family":"Cauchemez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"issue":"10","key":"pntd.0010818.ref001","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1590\/S0102-311X2006001000013","article-title":"[Frequency and spatial distribution of Aedes aegypti and Aedes albopictus (Diptera, Culicidae) in Rio de Janeiro, Brazil].","volume":"22","author":"T.N. de Lima\u2013Camara","year":"2006","journal-title":"Cad Saude Publica"},{"issue":"5","key":"pntd.0010818.ref002","first-page":"651","article-title":"Aedes aegypti (L.) and Aedes albopictus (Skuse) in Singapore City. 5. 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