{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:31:45Z","timestamp":1788406305157,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010848","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["KJ2020A0153"],"award-info":[{"award-number":["KJ2020A0153"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572801"],"award-info":[{"award-number":["81572801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["XJ202005"],"award-info":[{"award-number":["XJ202005"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Ocular toxoplasmosis (OT) is one of the most common causes of posterior uveitis. However, the pathogenic mechanisms of OT have not been well elucidated. Here, we used C57BL\/6 (B6) mice to establish OT by peroral infection with 20 cysts of the TgCtWh6 strain, and severe ocular damage was observed by histopathological analysis in the eyes of infected mice. RNA-sequencing results showed that infection with <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> increased the expression of the NK-mediated cytotoxicity gene pathway at Day 30 after ocular <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> infection. Both NK-cell and CD49a<jats:sup>+<\/jats:sup> NK-cell subsets are increased in ocular tissues, and the expression levels of LFA-1 in NK cells and ICAM-1 in the OT murine model were upregulated upon infection. Furthermore, inhibition of the interaction between LFA-1 and ICAM-1 with lifitegrast, a novel small molecule integrin antagonist, inhibited the protein expression of LFA-1 and ICAM-1 in murine OT and NK cells, improved the pathology of murine OT and influenced the secretion of cytokines in the OT murine model. In conclusion, the interaction between LFA-1 and ICAM-1 plays a role in the early regulation of the CD49a<jats:sup>+<\/jats:sup> NK-cell proportion in an OT murine model. LFA-1\/ ICAM-1 may be a key molecule in the pathogenesis of OT, and may provide new insights for potential immunotherapy.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010848","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T17:42:42Z","timestamp":1665164562000},"page":"e0010848","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["LFA-1\/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model"],"prefix":"10.1371","volume":"16","author":[{"given":"Nannan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linding","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yien","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-7440","authenticated-orcid":true,"given":"Yihong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"issue":"11","key":"pntd.0010848.ref001","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3109\/00365548.2012.693197","article-title":"A review on human toxoplasmosis","volume":"44","author":"G Saadatnia","year":"2012","journal-title":"Scand J Infect Dis"},{"issue":"1","key":"pntd.0010848.ref002","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1442-9071.2012.02838.x","article-title":"Ocular toxoplasmosis II: clinical features, pathology and management","volume":"41","author":"NJ Butler","year":"2013","journal-title":"Clin Exp Ophthalmol"},{"issue":"15","key":"pntd.0010848.ref003","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1073\/pnas.1203190109","article-title":"Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages","volume":"109","author":"C Su","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pntd.0010848.ref004","doi-asserted-by":"crossref","first-page":"e53483","DOI":"10.1371\/journal.pone.0053483","article-title":"Genotypes and mouse virulence of Toxoplasma gondii isolates from animals and humans in China","volume":"8","author":"L Wang","year":"2013","journal-title":"PLoS One"},{"key":"pntd.0010848.ref005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/1756-3305-6-273","article-title":"Toxoplasma gondii prevalence in food animals and rodents in different regions of China: isolation, genotyping and mouse pathogenicity","volume":"6","author":"L Wang","year":"2013","journal-title":"Parasit Vectors"},{"key":"pntd.0010848.ref006","doi-asserted-by":"crossref","first-page":"104465","DOI":"10.1016\/j.micpath.2020.104465","article-title":"Serotyping, host genes and cytokines response in human ocular toxoplasmosis","volume":"148","author":"LE Mantilla-Muriel","year":"2020","journal-title":"Microb Pathog"},{"issue":"11","key":"pntd.0010848.ref007","doi-asserted-by":"crossref","first-page":"e2541","DOI":"10.1371\/journal.pntd.0002541","article-title":"Severe South American ocular toxoplasmosis is associated with decreased Ifn-gamma\/Il-17a and increased Il-6\/Il-13 intraocular levels","volume":"7","author":"A de-la-Torre","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pntd.0010848.ref008","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1590\/S0037-86822012000600020","article-title":"Genetic polymorphism for IFNgamma +874T\/A in patients with acute toxoplasmosis","volume":"45","author":"S Neves Ede","year":"2012","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1","key":"pntd.0010848.ref009","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1167\/iovs.10-5819","article-title":"CXCL10 is required to maintain T-cell populations and to control parasite replication during chronic ocular toxoplasmosis","volume":"52","author":"K Norose","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"pntd.0010848.ref010","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1371\/journal.ppat.0020049","article-title":"CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection","volume":"2","author":"IA Khan","year":"2006","journal-title":"PLoS Pathog"},{"issue":"1\u20132","key":"pntd.0010848.ref011","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jim.2011.01.014","article-title":"Sensitive and viable quantification of inside-out signals for LFA-1 activation in human cytotoxic lymphocytes by flow cytometry","volume":"366","author":"J Theorell","year":"2011","journal-title":"J Immunol Methods"},{"issue":"9","key":"pntd.0010848.ref012","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nri2381","article-title":"Formation and function of the lytic NK-cell immunological synapse","volume":"8","author":"JS Orange","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"pntd.0010848.ref013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/icb.2013.96","article-title":"Cell biological steps and checkpoints in accessing NK cell cytotoxicity","volume":"92","author":"EM Mace","year":"2014","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"pntd.0010848.ref014","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.4049\/jimmunol.173.6.3653","article-title":"LFA-1 contributes an early signal for NK cell cytotoxicity","volume":"173","author":"DF Barber","year":"2004","journal-title":"J Immunol"},{"issue":"346","key":"pntd.0010848.ref015","doi-asserted-by":"crossref","first-page":"ra96","DOI":"10.1126\/scisignal.2005629","article-title":"A signaling network stimulated by beta2 integrin promotes the polarization of lytic granules in cytotoxic cells","volume":"7","author":"M Zhang","year":"2014","journal-title":"Sci Signal"},{"issue":"3","key":"pntd.0010848.ref016","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"TM Bui","year":"2020","journal-title":"J Leukoc Biol"},{"issue":"9","key":"pntd.0010848.ref017","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.4049\/jimmunol.1100646","article-title":"ICAM-1: getting a grip on leukocyte adhesion","volume":"186","author":"EO Long","year":"2011","journal-title":"J Immunol"},{"key":"pntd.0010848.ref018","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.exer.2018.05.022","article-title":"The interactive effects of genetic polymorphisms within LFA-1\/ICAM-1\/GSK-3beta pathway and environmental hazards on the development of Graves\u2019 opthalmopathy","volume":"174","author":"G Yang","year":"2018","journal-title":"Exp Eye Res"},{"key":"pntd.0010848.ref019","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/1471-2407-12-455","article-title":"LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro","volume":"12","author":"S Ghislin","year":"2012","journal-title":"BMC Cancer"},{"issue":"1","key":"pntd.0010848.ref020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/IAI.68.1.407-410.2000","article-title":"Toxoplasma gondii infection induces gene expression and secretion of interleukin 1 (IL-1), IL-6, granulocyte-macrophage colony-stimulating factor, and intercellular adhesion molecule 1 by human retinal pigment epithelial cells","volume":"68","author":"CN Nagineni","year":"2000","journal-title":"Infect Immun"},{"issue":"11","key":"pntd.0010848.ref021","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1167\/iovs.12-10384","article-title":"Migration of toxoplasma gondii-infected dendritic cells across human retinal vascular endothelium","volume":"53","author":"JM Furtado","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"pntd.0010848.ref022","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/icb.2012.21","article-title":"Toxoplasma gondii tachyzoites cross retinal endothelium assisted by intercellular adhesion molecule-1 in vitro","volume":"90","author":"JM Furtado","year":"2012","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"pntd.0010848.ref023","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1167\/iovs.04-0580","article-title":"Deterioration of visual function as examined by electroretinograms in Toxoplasma gondii-infected IFN-gamma-knockout mice","volume":"46","author":"K Norose","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"pntd.0010848.ref024","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1556\/1886.2015.00045","article-title":"Experimental Models of Ocular Infection with Toxoplasma Gondii","volume":"5","author":"A Dukaczewska","year":"2015","journal-title":"Eur J Microbiol Immunol (Bp)"},{"key":"pntd.0010848.ref025","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tvjl.2016.05.018","article-title":"Molecular investigation on the occurrence of Toxoplasma gondii oocysts in cat feces using TOX-element and ITS-1 region targets","volume":"215","author":"W Chemoh","year":"2016","journal-title":"Vet J"},{"issue":"1","key":"pntd.0010848.ref026","first-page":"12895","article-title":"NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis","volume":"7","author":"W Lin","year":"2017","journal-title":"Sci RepPubMed Central PMCID"},{"issue":"10","key":"pntd.0010848.ref027","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1167\/iovs.03-0156","article-title":"IFN-gamma-regulated Toxoplasma gondii distribution and load in the murine eye","volume":"44","author":"K Norose","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"pntd.0010848.ref028","first-page":"742","article-title":"[Development of murine models of ocular toxoplasmosis and preliminary results of ocular inflammatory transcriptome]","volume":"32","author":"A Sauer","year":"2009","journal-title":"J Fr Ophtalmol"},{"issue":"12","key":"pntd.0010848.ref029","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1128\/IAI.71.12.7159-7163.2003","article-title":"Interleukin-10 and pathogenesis of murine ocular toxoplasmosis","volume":"71","author":"F Lu","year":"2003","journal-title":"Infect Immun"},{"issue":"8","key":"pntd.0010848.ref030","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.micron.2008.02.003","article-title":"Serum and aqueous humour cytokine response and histopathological alterations during ocular Toxoplasma gondii infection in C57BL\/6 mice","volume":"39","author":"KS Calabrese","year":"2008","journal-title":"Micron"},{"issue":"3","key":"pntd.0010848.ref031","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2249.2008.03692.x","article-title":"Immunity and Toxoplasma retinochoroiditis","volume":"153","author":"GR Wallace","year":"2008","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"pntd.0010848.ref032","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1172\/JCI66381","article-title":"Liver-resident NK cells confer adaptive immunity in skin-contact inflammation","volume":"123","author":"H Peng","year":"2013","journal-title":"J Clin Invest"},{"issue":"5","key":"pntd.0010848.ref033","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.167.5.1597","article-title":"Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion","volume":"167","author":"AL Corbi","year":"1988","journal-title":"J Exp Med"},{"issue":"3","key":"pntd.0010848.ref034","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/vcp.12526","article-title":"Feline leukocyte adhesion (CD18) deficiency caused by a deletion in the integrin beta2 (ITGB2) gene","volume":"46","author":"TR Bauer","year":"2017","journal-title":"Vet Clin Pathol"},{"issue":"4","key":"pntd.0010848.ref035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0976-500X.195920","article-title":"Lifitegrast: A novel drug for treatment of dry eye disease","volume":"7","author":"A Abidi","year":"2016","journal-title":"J Pharmacol Pharmacother"},{"issue":"2","key":"pntd.0010848.ref036","doi-asserted-by":"crossref","first-page":"e1005396","DOI":"10.1371\/journal.ppat.1005396","article-title":"The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection","volume":"12","author":"JP Gigley","year":"2016","journal-title":"PLoS Pathog"},{"issue":"6 Suppl 94","key":"pntd.0010848.ref037","first-page":"S24","article-title":"Natural killer cells dominate a Th-1 polarized response in Behcet\u2019s disease patients with uveitis","volume":"33","author":"UC Kucuksezer","year":"2015","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"pntd.0010848.ref038","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1084\/jem.20141678","article-title":"NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-gamma-IL-27 axis","volume":"212","author":"WP Chong","year":"2015","journal-title":"J Exp Med"},{"issue":"6","key":"pntd.0010848.ref039","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1189\/jlb.72.6.1117","article-title":"Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells","volume":"72","author":"N Kitaichi","year":"2002","journal-title":"J Leukoc Biol"},{"key":"pntd.0010848.ref040","doi-asserted-by":"crossref","first-page":"e01659","DOI":"10.7554\/eLife.01659","article-title":"Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells","volume":"3","author":"DK Sojka","year":"2014","journal-title":"Elife"},{"issue":"5","key":"pntd.0010848.ref041","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.immuni.2016.03.007","article-title":"Transforming Growth Factor-beta Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands","volume":"44","author":"VS Cortez","year":"2016","journal-title":"Immunity"},{"issue":"10","key":"pntd.0010848.ref042","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.4049\/jimmunol.1500651","article-title":"Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody","volume":"195","author":"F Victorino","year":"2015","journal-title":"J Immunol"},{"key":"pntd.0010848.ref043","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/sqb.2013.78.020354","article-title":"Tissue-resident natural killer cells","volume":"78","author":"WM Yokoyama","year":"2013","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"pntd.0010848.ref044","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47605","article-title":"Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells","volume":"8","author":"E Park","year":"2019","journal-title":"Elife"},{"issue":"9","key":"pntd.0010848.ref045","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1158\/2326-6066.CIR-18-0757","article-title":"Accumulation of Tumor-Infiltrating CD49a(+) NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma","volume":"7","author":"H Sun","year":"2019","journal-title":"Cancer Immunol Res"},{"issue":"6","key":"pntd.0010848.ref046","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.4049\/jimmunol.1402756","article-title":"Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells","volume":"194","author":"N Marquardt","year":"2015","journal-title":"J Immunol"},{"key":"pntd.0010848.ref047","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3389\/fimmu.2020.01676","article-title":"Characterization of Rhesus Macaque Liver-Resident CD49a(+) NK Cells During Retrovirus Infections","volume":"11","author":"DR Ram","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"pntd.0010848.ref048","doi-asserted-by":"crossref","first-page":"e13101","DOI":"10.1111\/aji.13101","article-title":"CD49a regulates the function of human decidual natural killer cells","volume":"81","author":"H Li","year":"2019","journal-title":"Am J Reprod Immunol"},{"key":"pntd.0010848.ref049","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fimmu.2019.00477","article-title":"gammadeltaT Cells Suppress Liver Fibrosis via Strong Cytolysis and Enhanced NK Cell-Mediated Cytotoxicity Against Hepatic Stellate Cells","volume":"10","author":"M Liu","year":"2019","journal-title":"Front Immunol"},{"issue":"10","key":"pntd.0010848.ref050","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.173.10.6418","article-title":"CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation","volume":"173","author":"N Dalbeth","year":"2004","journal-title":"J Immunol"},{"issue":"7","key":"pntd.0010848.ref051","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.4049\/jimmunol.180.7.4495","article-title":"In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses","volume":"180","author":"R Winkler-Pickett","year":"2008","journal-title":"J Immunol"},{"issue":"11","key":"pntd.0010848.ref052","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/eji.200838882","article-title":"Killers and beyond: NK-cell-mediated control of immune responses","volume":"38","author":"CE Andoniou","year":"2008","journal-title":"Eur J Immunol"},{"issue":"2","key":"pntd.0010848.ref053","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1182\/blood-2004-10-4035","article-title":"NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor","volume":"106","author":"M Vitale","year":"2005","journal-title":"Blood"},{"issue":"12","key":"pntd.0010848.ref054","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ni1138","article-title":"Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming","volume":"5","author":"A Martin-Fontecha","year":"2004","journal-title":"Nat Immunol"},{"issue":"12","key":"pntd.0010848.ref055","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.4049\/jimmunol.0902598","article-title":"NK cell regulation of CD4 T cell-mediated graft-versus-host disease","volume":"184","author":"M Noval Rivas","year":"2010","journal-title":"J Immunol"},{"issue":"4","key":"pntd.0010848.ref056","doi-asserted-by":"crossref","first-page":"470","DOI":"10.5114\/ceji.2015.56971","article-title":"The role of natural killer cells in pathogenesis of autoimmune diseases","volume":"40","author":"K Popko","year":"2015","journal-title":"Cent Eur J Immunol"},{"issue":"2","key":"pntd.0010848.ref057","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40265-016-0681-1","article-title":"Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease","volume":"77","author":"GM Keating","year":"2017","journal-title":"Drugs"},{"issue":"1","key":"pntd.0010848.ref058","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/jop.2016.0105","article-title":"LFA-1\/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease","volume":"33","author":"SC Pflugfelder","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"issue":"10","key":"pntd.0010848.ref059","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1167\/iovs.09-5144","article-title":"Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR)","volume":"51","author":"VR Rao","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"pntd.0010848.ref060","first-page":"2563","article-title":"Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis","volume":"42","author":"MD Becker","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"pntd.0010848.ref061","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jtos.2016.01.001","article-title":"Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease","volume":"14","author":"VL Perez","year":"2016","journal-title":"Ocul Surf"},{"issue":"4","key":"pntd.0010848.ref062","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/07853890.2013.792495","article-title":"Regulation of self-ligands for activating natural killer cell receptors","volume":"45","author":"RA Lam","year":"2013","journal-title":"Ann Med"},{"issue":"11","key":"pntd.0010848.ref063","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2009-08-238469","article-title":"Regulation of human NK-cell cytokine and chemokine production by target cell recognition","volume":"115","author":"C Fauriat","year":"2010","journal-title":"Blood"},{"issue":"2","key":"pntd.0010848.ref064","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajo.2008.08.032","article-title":"Tear cytokine profiles in dysfunctional tear syndrome","volume":"147","author":"H Lam","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"pntd.0010848.ref065","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1462-5822.2005.00486.x","article-title":"Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2","volume":"7","author":"A Barragan","year":"2005","journal-title":"Cell Microbiol"},{"issue":"6","key":"pntd.0010848.ref066","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1167\/iovs.06-0598","article-title":"Unique gene expression profiles of donor-matched human retinal and choroidal vascular endothelial cells","volume":"48","author":"JR Smith","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"pntd.0010848.ref067","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0196-9781(03)00083-4","article-title":"Targeting ICAM-1\/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors","volume":"24","author":"ME Anderson","year":"2003","journal-title":"Peptides"},{"issue":"5","key":"pntd.0010848.ref068","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1007\/s12035-018-1277-4","article-title":"Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases","volume":"56","author":"T Yagami","year":"2019","journal-title":"Mol Neurobiol"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0010848","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:47:37Z","timestamp":1666201657000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0010848"}},"subtitle":[],"editor":[{"given":"Jorge Enrique","family":"Gomez-Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0010848","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pntd.0010848","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]}}}