{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:46:18Z","timestamp":1783406778081,"version":"3.54.6"},"update-to":[{"DOI":"10.1371\/journal.pntd.0010852","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Human Heredity and Health in Africa","award":["H3Africa\u00a0[H3A-18-004]"],"award-info":[{"award-number":["H3Africa\u00a0[H3A-18-004]"]}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"crossref","award":["SGPIII\/0210\/388"],"award-info":[{"award-number":["SGPIII\/0210\/388"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MTN\/OCEAC Project"},{"name":"University of Dschang"},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Yaounde 1."}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Schistosomiasis control relies mainly on mass drug administration of Praziquantel (PZQ) to school aged children (SAC). Although precision mapping has recently guided decision making, the sub-districts and the epidemiological differences existing between bio-ecological settings in which infected children come from were not taken into consideration. This study was designed to fill this gap by using POC-CCA and KK to comparatively determine the prevalence and infection intensities of <jats:italic>Schistosoma mansoni (S<\/jats:italic>. <jats:italic>mansoni)<\/jats:italic> and to perform fine-scale mapping of <jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic> infections and its infection intensities with the overarching goal of identifying sub-districts presenting high transmission risk where control operations must be boosted to achieve schistosomiasis elimination.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methodology<\/jats:title>\n<jats:p>During a cross- sectional study conducted in Makenene, 1773 stool and 2253 urine samples were collected from SAC of ten primary schools. <jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic> infections were identified using the point of care circulating cathodic antigen (POC-CCA) and Kato-Katz (KK) test respectively on urine and stool samples. Geographical coordinates of houses of infected SAC were recorded using a global position system device. Schistosome infections and infection intensities were map using QGIS software.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The prevalence of <jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic> inferred from POC-CCA and KK were 51.3% and 7.3% respectively. Most infected SAC and those bearing heavy infections intensities were clustered in sub-districts of Baloua, Mock-sud and Carri\u00e8re. Houses with heavily-infected SAC were close to risky biotopes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study confirms the low sensitivity of KK test compared to POC-CCA to accurately identify children with schistosome infection and bearing different schistosome burden. Fine-scale mapping of schistosome infections and infection intensities enabled to identify high transmission sub-districts where control measures must be boosted to reach schistosomiasis elimination.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0010852","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T18:03:11Z","timestamp":1665684191000},"page":"e0010852","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fine-scale mapping of Schistosoma mansoni infections and infection intensities in sub-districts of Makenene in the Centre region of Cameroon"],"prefix":"10.1371","volume":"16","author":[{"given":"Estelle Mezajou","family":"Mewamba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnol Auvaker Zebaze","family":"Tiofack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille Nguemnang","family":"Kamdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esthelline Yangea","family":"Tchounkeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostand Jo\u00ebl Atiokeng","family":"Tatang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic Edmond Tekeu","family":"Mengoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mureille Carole Tchami","family":"Mbagnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flobert","family":"Njiokou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Casacuberta-Partal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilaire Macaire","family":"Womeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-818X","authenticated-orcid":true,"given":"Gustave","family":"Simo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the TrypanoGEN+ research group of the H3Africa consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"issue":"2","key":"pntd.0010852.ref001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/20786190.2014.978121","article-title":"A study of hurdles in mass treatment of Schistosomiasis in Kwazulu-Natal, South Africa.","volume":"57","author":"A. 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