{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:09:27Z","timestamp":1790208567901,"version":"4.1.0"},"reference-count":122,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022719","name":"Darwin Trust of Edinburgh","doi-asserted-by":"publisher","award":["PhD studentship"],"award-info":[{"award-number":["PhD studentship"]}],"id":[{"id":"10.13039\/501100022719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011949","name":"Islamic Research and Training Institute","doi-asserted-by":"publisher","award":["PhD studentship"],"award-info":[{"award-number":["PhD studentship"]}],"id":[{"id":"10.13039\/501100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Members of <jats:italic>Cryptococcus gattii\/neoformans<\/jats:italic> species complex are the etiological agents of the potentially fatal human fungal infection cryptococcosis. <jats:italic>C<\/jats:italic>. <jats:italic>gattii<\/jats:italic> and its sister species cause disease in both immunocompetent and immunocompromised hosts, while the closely related species <jats:italic>C<\/jats:italic>. <jats:italic>neoformans and C<\/jats:italic>. <jats:italic>deneoformans<\/jats:italic> predominantly infect immunocompromised hosts. To date, most studies have focused on similarities in pathogenesis between these two groups, but over recent years, important differences have become apparent. In this review paper, we highlight some of the major phenotypic differences between the <jats:italic>C<\/jats:italic>. <jats:italic>gattii<\/jats:italic> and <jats:italic>neoformans<\/jats:italic> species complexes and justify the need to study the virulence and pathogenicity of the <jats:italic>C<\/jats:italic>. <jats:italic>gattii<\/jats:italic> species complex as a distinct cryptococcal group.<\/jats:p>","DOI":"10.1371\/journal.pntd.0010916","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T18:30:56Z","timestamp":1671129056000},"page":"e0010916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Cryptococcus gattii species complex: Unique pathogenic yeasts with understudied virulence mechanisms"],"prefix":"10.1371","volume":"16","author":[{"given":"Lamin","family":"Saidykhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinaemerem U.","family":"Onyishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-1838","authenticated-orcid":true,"given":"Robin C.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"issue":"6","key":"pntd.0010916.ref001","first-page":"689","article-title":"An atypical strain of Cryptococcus neoformans (San Felice) Vuillemin 1894. 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