{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:52:08Z","timestamp":1784098328184,"version":"3.55.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005430","name":"American Society for Microbiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005430","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people. However, despite their kinship, they are vectored by different mosquito subfamilies that diverged 180 million years ago (anopheline versus culicine subfamilies). Previous work indicated that the nonstructural protein 3 (nsP3) of these alphaviruses was partially responsible for this vector specificity. To better understand the cellular components controlling alphavirus vector specificity, a cell culture model system of the anopheline restriction of CHIKV was developed along with a protein expression strategy. Mosquito proteins that differentially interacted with CHIKV nsP3 or ONNV nsP3 were identified. Six proteins were identified that specifically bound ONNV nsP3, ten that bound CHIKV nsP3 and eight that interacted with both. In addition to identifying novel factors that may play a role in virus\/vector processing, these lists included host proteins that have been previously implicated as contributing to alphavirus replication.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011028","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:26:18Z","timestamp":1674671178000},"page":"e0011028","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-5940","authenticated-orcid":true,"given":"Nathaniel M.","family":"Byers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Stuchlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Ledermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"issue":"6","key":"pntd.0011028.ref001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/20477724.2017.1355431","article-title":"O\u2019nyong-nyong fever: a neglected mosquito-borne viral disease","volume":"111","author":"G Rezza","year":"2017","journal-title":"Pathog Glob Health"},{"key":"pntd.0011028.ref002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0035-9203(61)90017-7","article-title":"O\u2019nyong-nyong fever: an epidemic virus disease in East Africa. II. Isolation and some properties of the virus","volume":"55","author":"MC Williams","year":"1961","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"pntd.0011028.ref003","doi-asserted-by":"crossref","first-page":"e0003436","DOI":"10.1371\/journal.pntd.0003436","article-title":"High rates of o\u2019nyong nyong and Chikungunya virus transmission in coastal Kenya","volume":"9","author":"AD LaBeaud","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0011028.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.onehlt.2017.06.001","article-title":"Emerging arboviruses: Why today?","volume":"4","author":"E Gould","year":"2017","journal-title":"One Health"},{"issue":"2","key":"pntd.0011028.ref005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.virol.2009.07.024","article-title":"Replication cycle of chikungunya: a re-emerging arbovirus","volume":"393","author":"M Solignat","year":"2009","journal-title":"Virology"},{"issue":"Pt 2","key":"pntd.0011028.ref006","first-page":"471","article-title":"Re-emergence of Chikungunya and O\u2019nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships","volume":"81","author":"AM Powers","year":"2000","journal-title":"J Gen Virol"},{"issue":"1","key":"pntd.0011028.ref007","doi-asserted-by":"crossref","first-page":"18823","DOI":"10.1038\/s41598-020-74883-3","article-title":"Culicidae evolutionary history focusing on the Culicinae subfamily based on mitochondrial phylogenomics","volume":"10","author":"AF da Silva","year":"2020","journal-title":"Scientific Reports"},{"key":"pntd.0011028.ref008","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0035-9203(65)90012-X","article-title":"O\u2019nyong-Nyong Fever: An Epidemic Virus Disease in East Africa. 8. Virus Isolations from Anopheles Mosquitoes","volume":"59","author":"MC Williams","year":"1965","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"pntd.0011028.ref009","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/jmedent\/7.5.615","article-title":"Attempts to transmit Chikungunya virus with six species of mosquito","volume":"7","author":"BM McIntosh","year":"1970","journal-title":"Journal of medical entomology"},{"issue":"5","key":"pntd.0011028.ref010","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4269\/ajtmh.2005.72.616","article-title":"Differential infectivities of o\u2019nyong-nyong and chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes","volume":"72","author":"DL Vanlandingham","year":"2005","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"pntd.0011028.ref011","doi-asserted-by":"crossref","first-page":"e1931","DOI":"10.1371\/journal.pntd.0001931","article-title":"O\u2019nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3","volume":"7","author":"KD Saxton-Shaw","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"pntd.0011028.ref012","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1128\/jvi.68.10.6466-6475.1994","article-title":"Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA","volume":"68","author":"YF Wang","year":"1994","journal-title":"J Virol"},{"issue":"9","key":"pntd.0011028.ref013","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1128\/jvi.68.9.5781-5791.1994","article-title":"Genetic analysis of the nsP3 region of Sindbis virus: evidence for roles in minus-strand and subgenomic RNA synthesis","volume":"68","author":"MW LaStarza","year":"1994","journal-title":"J Virol"},{"key":"pntd.0011028.ref014","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/s13071-015-1070-4","article-title":"Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus","volume":"8","author":"JJ Fros","year":"2015","journal-title":"Parasit Vectors"},{"key":"pntd.0011028.ref015","doi-asserted-by":"crossref","first-page":"625711","DOI":"10.3389\/fcell.2021.625711","article-title":"A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins","volume":"9","author":"G Nowee","year":"2021","journal-title":"Frontiers in cell and developmental biology"},{"issue":"3","key":"pntd.0011028.ref016","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/v10030105","article-title":"The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last","volume":"10","author":"B Gotte","year":"2018","journal-title":"Viruses"},{"key":"pntd.0011028.ref017","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.3389\/fmicb.2017.02652","article-title":"Interactions of Alphavirus nsP3 Protein with Host Proteins","volume":"8","author":"T Lark","year":"2017","journal-title":"Front Microbiol"},{"issue":"1","key":"pntd.0011028.ref018","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jmb.2008.10.045","article-title":"Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites","volume":"385","author":"M Neuvonen","year":"2009","journal-title":"J Mol Biol"},{"issue":"6","key":"pntd.0011028.ref019","doi-asserted-by":"crossref","DOI":"10.3390\/v13061021","article-title":"The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence","volume":"13","author":"N Abdullah","year":"2021","journal-title":"Viruses"},{"issue":"4","key":"pntd.0011028.ref020","article-title":"The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation","volume":"12","author":"YMO Alhammad","year":"2020","journal-title":"Viruses"},{"key":"pntd.0011028.ref021","doi-asserted-by":"crossref","first-page":"41746","DOI":"10.1038\/srep41746","article-title":"The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases","volume":"7","author":"L Eckei","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"pntd.0011028.ref022","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1073\/pnas.1621485114","article-title":"ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence","volume":"114","author":"RL McPherson","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pntd.0011028.ref023","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021719118","article-title":"Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity","volume":"118","author":"AK Jayabalan","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pntd.0011028.ref024","doi-asserted-by":"crossref","first-page":"e0245013","DOI":"10.1371\/journal.pone.0245013","article-title":"Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design","volume":"16","author":"S Zhang","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"pntd.0011028.ref025","doi-asserted-by":"crossref","first-page":"e1007239","DOI":"10.1371\/journal.ppat.1007239","article-title":"Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription","volume":"15","author":"Y Gao","year":"2019","journal-title":"PLoS pathogens"},{"issue":"3","key":"pntd.0011028.ref026","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1128\/jvi.63.3.1326-1337.1989","article-title":"Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication","volume":"63","author":"GP Li","year":"1989","journal-title":"J Virol"},{"issue":"10","key":"pntd.0011028.ref027","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1128\/JVI.80.10.4992-4997.2006","article-title":"Effects of an opal termination codon preceding the nsP4 gene sequence in the O\u2019Nyong-Nyong virus genome on Anopheles gambiae infectivity","volume":"80","author":"KM Myles","year":"2006","journal-title":"J Virol"},{"issue":"1","key":"pntd.0011028.ref028","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/viro.1998.9437","article-title":"Emergence of epidemic O\u2019nyong-nyong fever in Uganda after a 35-year absence: genetic characterization of the virus","volume":"252","author":"RS Lanciotti","year":"1998","journal-title":"Virology"},{"key":"pntd.0011028.ref029","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"C Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"pntd.0011028.ref030","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.160078","article-title":"Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication","volume":"6","author":"T Schulte","year":"2016","journal-title":"Open Biol"},{"issue":"9","key":"pntd.0011028.ref031","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02276-20","article-title":"Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication","volume":"95","author":"M Teppor","year":"2021","journal-title":"J Virol"},{"issue":"5","key":"pntd.0011028.ref032","doi-asserted-by":"crossref","DOI":"10.3390\/v10050226","article-title":"Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus","volume":"10","author":"M Mutso","year":"2018","journal-title":"Viruses"},{"issue":"1","key":"pntd.0011028.ref033","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03253-19","article-title":"Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice","volume":"11","author":"R Abraham","year":"2020","journal-title":"mBio"},{"issue":"5","key":"pntd.0011028.ref034","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1073\/pnas.040568397","article-title":"Toward Anopheles transformation: Minos element activity in anopheline cells and embryos","volume":"97","author":"F Catteruccia","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pntd.0011028.ref035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0035-9203(72)90068-5","article-title":"A mosquito cell line (MOS. 55) from Anopheles gambiae larva","volume":"66","author":"Z Marhoul","year":"1972","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6","key":"pntd.0011028.ref036","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.0962-1075.2004.00521.x","article-title":"Infection patterns of o\u2019nyong nyong virus in the malaria-transmitting mosquito, Anopheles gambiae","volume":"13","author":"AC Brault","year":"2004","journal-title":"Insect Mol Biol"},{"issue":"Pt 7","key":"pntd.0011028.ref037","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1099\/vir.0.060764-0","article-title":"Sunguru virus: a novel virus in the family Rhabdoviridae isolated from a chicken in north-western Uganda","volume":"95","author":"JP Ledermann","year":"2014","journal-title":"J Gen Virol"},{"issue":"12","key":"pntd.0011028.ref038","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1128\/jvi.68.12.7728-7737.1994","article-title":"Suppression of apoptosis in insect cells stably transfected with baculovirus p35: dominant interference by N-terminal sequences p35(1\u201376)","volume":"68","author":"JL Cartier","year":"1994","journal-title":"J Virol"},{"issue":"12","key":"pntd.0011028.ref039","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1128\/JVI.00373-12","article-title":"A conserved N-terminal domain mediates required DNA replication activities and phosphorylation of the transcriptional activator IE1 of Autographa californica multicapsid nucleopolyhedrovirus","volume":"86","author":"DJ Taggart","year":"2012","journal-title":"J Virol"},{"issue":"D1","key":"pntd.0011028.ref040","doi-asserted-by":"crossref","first-page":"D7","DOI":"10.1093\/nar\/gkv1290","article-title":"Database resources of the National Center for Biotechnology Information","volume":"44","author":"NCBI Resource Coordinators","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"pntd.0011028.ref041","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"D Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"pntd.0011028.ref042","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"pntd.0011028.ref043","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"TU Consortium","year":"2020","journal-title":"Nucleic Acids Research"},{"issue":"11","key":"pntd.0011028.ref044","doi-asserted-by":"crossref","first-page":"e0006958","DOI":"10.1371\/journal.pntd.0006958","article-title":"Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes","volume":"12","author":"GP G\u00f6ertz","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0011028.ref045","article-title":"Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode","author":"CD Meshram","year":"2018","journal-title":"J Virol"},{"issue":"11","key":"pntd.0011028.ref046","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"8","key":"pntd.0011028.ref047","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3390\/v13081533","article-title":"Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3","volume":"13","author":"A Bakovic","year":"2021","journal-title":"Viruses"},{"issue":"14","key":"pntd.0011028.ref048","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00371-17","article-title":"Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly","volume":"91","author":"I Frolov","year":"2017","journal-title":"J Virol"},{"issue":"19","key":"pntd.0011028.ref049","doi-asserted-by":"crossref","first-page":"10873","DOI":"10.1128\/JVI.01506-12","article-title":"Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci","volume":"86","author":"JJ Fros","year":"2012","journal-title":"J Virol"},{"issue":"8","key":"pntd.0011028.ref050","doi-asserted-by":"crossref","first-page":"e1005810","DOI":"10.1371\/journal.ppat.1005810","article-title":"New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes","volume":"12","author":"DY Kim","year":"2016","journal-title":"PLoS Pathog"},{"issue":"D1","key":"pntd.0011028.ref051","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gkz991","article-title":"CDD\/SPARCLE: the conserved domain database in 2020","volume":"48","author":"S Lu","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"pntd.0011028.ref052","doi-asserted-by":"crossref","first-page":"W327","DOI":"10.1093\/nar\/gkh454","article-title":"CD-Search: protein domain annotations on the fly","volume":"32","author":"A Marchler-Bauer","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"pntd.0011028.ref053","doi-asserted-by":"crossref","first-page":"D225","DOI":"10.1093\/nar\/gkq1189","article-title":"CDD: a Conserved Domain Database for the functional annotation of proteins","volume":"39","author":"A Marchler-Bauer","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"pntd.0011028.ref054","doi-asserted-by":"crossref","first-page":"16168","DOI":"10.3390\/ijms140816168","article-title":"Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins","volume":"14","author":"Y Ji","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"8","key":"pntd.0011028.ref055","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.80.8.4122-4134.2006","article-title":"Formation of nsP3-specific protein complexes during Sindbis virus replication","volume":"80","author":"E Frolova","year":"2006","journal-title":"J Virol"},{"issue":"15","key":"pntd.0011028.ref056","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1128\/JVI.00477-10","article-title":"Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomes","volume":"84","author":"P Spuul","year":"2010","journal-title":"J Virol"},{"issue":"4","key":"pntd.0011028.ref057","doi-asserted-by":"crossref","first-page":"e61444","DOI":"10.1371\/journal.pone.0061444","article-title":"Differential proteome analysis of chikungunya virus infection on host cells","volume":"8","author":"CL Thio","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"pntd.0011028.ref058","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/rmv.722","article-title":"Phosphorylation events during viral infections provide potential therapeutic targets","volume":"22","author":"JA Keating","year":"2012","journal-title":"Rev Med Virol"},{"issue":"2","key":"pntd.0011028.ref059","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12250-019-00122-3","article-title":"Viral Regulation of RNA Granules in Infected Cells","volume":"34","author":"Q Zhang","year":"2019","journal-title":"Virol Sin"},{"key":"pntd.0011028.ref060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.antiviral.2016.04.008","article-title":"Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells","volume":"131","author":"M Amaya","year":"2016","journal-title":"Antiviral Res"},{"key":"pntd.0011028.ref061","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fcell.2019.00190","article-title":"Directing Traffic: Regulation of COPI Transport by Post-translational Modifications","volume":"7","author":"PM Luo","year":"2019","journal-title":"Frontiers in cell and developmental biology"},{"issue":"Pt 9","key":"pntd.0011028.ref062","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1099\/vir.0.012682-0","article-title":"Interaction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells","volume":"90","author":"E Park","year":"2009","journal-title":"J Gen Virol"},{"issue":"15","key":"pntd.0011028.ref063","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.1128\/JVI.00733-12","article-title":"New PARP gene with an anti-alphavirus function","volume":"86","author":"S Atasheva","year":"2012","journal-title":"J Virol"},{"issue":"4","key":"pntd.0011028.ref064","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1128\/JVI.03443-13","article-title":"Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication","volume":"88","author":"S Atasheva","year":"2014","journal-title":"J Virol"},{"issue":"2","key":"pntd.0011028.ref065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1074-7613(02)00368-0","article-title":"Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression","volume":"17","author":"J Park","year":"2002","journal-title":"Immunity"},{"issue":"1","key":"pntd.0011028.ref066","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12013-013-9637-1","article-title":"The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention","volume":"67","author":"MA Villamil","year":"2013","journal-title":"Cell Biochem Biophys"},{"issue":"49","key":"pntd.0011028.ref067","doi-asserted-by":"crossref","first-page":"46230","DOI":"10.1074\/jbc.M108177200","article-title":"Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins","volume":"276","author":"SK Mishra","year":"2001","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"pntd.0011028.ref068","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1042\/BST0380187","article-title":"The Sla2p\/HIP1\/HIP1R family: similar structure, similar function in endocytosis?","volume":"38","author":"I Gottfried","year":"2010","journal-title":"Biochem Soc Trans"},{"issue":"9","key":"pntd.0011028.ref069","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1600-0854.2009.00922.x","article-title":"Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis","volume":"10","author":"J Borlido","year":"2009","journal-title":"Traffic"},{"issue":"36","key":"pntd.0011028.ref070","doi-asserted-by":"crossref","first-page":"22462","DOI":"10.1073\/pnas.2006914117","article-title":"Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans","volume":"117","author":"H Jiang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"31","key":"pntd.0011028.ref071","doi-asserted-by":"crossref","first-page":"16307","DOI":"10.1074\/jbc.M116.732412","article-title":"Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2","volume":"291","author":"H Tossavainen","year":"2016","journal-title":"The Journal of biological chemistry"},{"issue":"11","key":"pntd.0011028.ref072","doi-asserted-by":"crossref","first-page":"e1002383","DOI":"10.1371\/journal.ppat.1002383","article-title":"SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication","volume":"7","author":"M Neuvonen","year":"2011","journal-title":"PLoS pathogens"},{"key":"pntd.0011028.ref073","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.virol.2019.08.022","article-title":"Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein","volume":"537","author":"P Agback","year":"2019","journal-title":"Virology"},{"issue":"5","key":"pntd.0011028.ref074","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1128\/JVI.02073-06","article-title":"The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff","volume":"81","author":"N Garmashova","year":"2007","journal-title":"J Virol"},{"issue":"13","key":"pntd.0011028.ref075","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1128\/JVI.00137-07","article-title":"Viral alteration of cellular translational machinery increases defective ribosomal products","volume":"81","author":"P Berglund","year":"2007","journal-title":"J Virol"},{"issue":"3","key":"pntd.0011028.ref076","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00203-020-02094-5","article-title":"Selective regulation in ribosome biogenesis and protein production for efficient viral translation","volume":"203","author":"HJ Dong","year":"2021","journal-title":"Arch Microbiol"},{"issue":"2","key":"pntd.0011028.ref077","doi-asserted-by":"crossref","first-page":"e00029","DOI":"10.1128\/mBio.00029-16","article-title":"Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries","volume":"7","author":"S Karniely","year":"2016","journal-title":"mBio"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0011028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:26:54Z","timestamp":1674671214000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0011028"}},"subtitle":[],"editor":[{"given":"Abdallah M.","family":"Samy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0011028","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,25]]}}}