{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:22:34Z","timestamp":1782166954609,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011084","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019191","name":"Texas A&M AgriLife Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019191","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019191","name":"Texas A&M AgriLife Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019191","id-type":"DOI","asserted-by":"crossref"}]},{"name":"USDA NIFA Animal Health and Disease Research Capacity Funding"},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02980"],"award-info":[{"award-number":["02980"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Canine Chagas disease is caused by the protozoan parasite <jats:italic>Trypanosoma cruzi<\/jats:italic> and transmitted by insect triatomine vectors known as kissing bugs. The agent can cause cardiac damage and long-term heart disease and death in humans, dogs, and other mammals. In laboratory settings, treatment of dogs with systemic insecticides has been shown to be highly efficacious at killing triatomines that feed on treated dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>We developed compartmental vector-host models of <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> transmission between the triatomine and dog population accounting for the impact of seasonality and triatomine migration on disease transmission dynamics. We considered a single vector-host model without seasonality, and model with seasonality, and a spatially coupled model. We used the models to evaluate the effectiveness of the insecticide fluralaner with different durations of treatment regimens for reducing <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> infection in different transmission settings.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In low and medium transmission settings, our model showed a marginal difference between the 3-month and 6-month regimens for reducing <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> infection among dogs. The difference increases in the presence of seasonality and triatomine migration from a sylvatic transmission setting. In high transmission settings, the 3-month regimen was substantially more effective in reducing <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> infections in dogs than the other regimens. Our model showed that increased migration rate reduces fluralaner effectiveness in all treatment regimens, but the relative reduction in effectiveness is minimal during the first years of treatment. However, if an additional 10% or more of triatomines killed by dog treatment were eaten by dogs, treatment could increase <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> infections in the dog population at least during the first year of treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our analysis shows that treating all peridomestic dogs every three to six months for at least five years could be an effective measure to reduce <jats:italic>T<\/jats:italic>. <jats:italic>cruzi<\/jats:italic> infections in dogs and triatomines in peridomestic transmission settings. However, further studies at the local scale are needed to better understand the potential impact of routine use of fluralaner treatment on increasing dogs\u2019 consumption of dead triatomines.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0011084","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T18:33:55Z","timestamp":1674585235000},"page":"e0011084","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study"],"prefix":"10.1371","volume":"17","author":[{"given":"Edem","family":"Fiatsonu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Busselman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel L.","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-7613","authenticated-orcid":true,"given":"Martial L.","family":"Ndeffo-Mbah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"pntd.0011084.ref001","unstructured":"Pan American Health Organization PAHO. 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