{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:47:29Z","timestamp":1792788449491,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011201","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000}}],"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangzhou basic research program on people\u2019s Livelihood Science and technology","award":["202002020005"],"award-info":[{"award-number":["202002020005"]}]},{"name":"Basic and applied basic research project jointly funded by hospital (College) of Guangzhou","award":["202201020285"],"award-info":[{"award-number":["202201020285"]}]},{"name":"Basic and applied basic research project jointly funded by hospital (College) of Guangzhou","award":["202201020276"],"award-info":[{"award-number":["202201020276"]}]},{"name":"Medical Key Discipline Program of Guangzhou-Viral Infectious Diseases","award":["2021-2023"],"award-info":[{"award-number":["2021-2023"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"\n Objectives<\/jats:title>\n \n This study aimed to investigate the influencing factors of delayed clearance of\n Talaromyces marneffei<\/jats:italic>\n (\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n ) in blood culture of patients with acquired immune deficiency syndrome (AIDS) complicated with talaromycosis after antifungal therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The patients with AIDS complicated with talaromycosis were retrospectively enrolled, and divided into two groups according to the blood\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n culture results in two weeks after antifungal therapy. The baseline clinical data were collected and the antifungal susceptibility of\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n was tested.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 190 patients with AIDS and talaromycosis were enrolled, of whom 101 cases remained positive for\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n (Pos-group) while the other 89 cases were negative in blood culture (Neg-group) after two weeks\u2019 antifungal treatment. The Pos-group had a higher baseline Aspartate aminotransferase (AST, 78.5 vs. 105 U\/L;\n P<\/jats:italic>\n = 0.073) and lower CD4+ T cells level (11 vs. 7 cells\/\u03bcl;\n P<\/jats:italic>\n = 0.061). The percentage of isolates with higher MICs of voriconazole (VOR) and fluconazole (FLU) in the Pos-group were significantly higher than those in the Neg-group (\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n = 12.623,\n P<\/jats:italic>\n < 0.001 and\n \u03c7<\/jats:italic>\n \n 2<\/jats:italic>\n <\/jats:sup>\n = 9.356,\n P<\/jats:italic>\n = 0.002, respectively). By multivariate logistic regression, the MIC value for VOR was identified as the prognostic variable that may influence the clearance of\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n in blood culture after antifungal therapy among AIDS patients with talaromycosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The delayed negative conversion of blood\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n -culture may be associated with some factors especially higher MIC of VOR, indicating the possibility of drug resistance of\n T<\/jats:italic>\n .\n marneffei<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pntd.0011201","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:09:16Z","timestamp":1680530956000},"page":"e0011201","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["The delayed clearance of Talaromyces marneffei in blood culture may be associated with higher MIC of voriconazole after antifungal therapy among AIDS patients with 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