{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:46:58Z","timestamp":1790628418110,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011242","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000}}],"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Snakebite (SB) envenoming is an acute emergency requiring an early care delivery. We aimed to search for the time to reach healthcare facilities in various regions of French Guiana (FG) and to assess the impact of time to antivenom (AV) on the correction of coagulation parameters in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This is a prospective observational study conducted in Cayenne General Hospital between January 1st, 2016, and July 31st, 2022. We included all patients hospitalized for SB envenoming less than 48h after the bite, and receiving antivenom (AV). We assessed the time lapse between SB and medical attention and the time needed to return of the coagulation parameters to normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Principal findings<\/jats:title>\n                    <jats:p>\n                      Overall, 119 patients were investigated, and 48.7% were from remote areas. The median time from SB to AV therapy was 09:15 h (05:32\u201317:47). The time was longer in patients from remote rural locations. AV was dispensed within the first six hours after the SB in 45 cases (37.8%). Time from SB to reaching normal plasma fibrinogen concentration was 23:27 h (20:00\u201327:10) in patients receiving AV\u22646h\n                      <jats:italic>vs<\/jats:italic>\n                      . 31:23 h (24:00\u201345:05) in those receiving AV&gt;6h (p&lt;0.001). Whereas, the time from AV administration to reach normal fibrinogen dosage was similar in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients from rural settings in FG suffer from a delay in AV administration after SB envenoming leading to an extended time in which patients are coagulopathic. Once AV is administered, clotting parameters recover at a similar rate. Supplying remote healthcare facilities with AV and with medical teams trained on its use should be planned.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0011242","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T13:39:02Z","timestamp":1682343542000},"page":"e0011242","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of the time to antivenom administration on recovery from snakebite envenoming-related coagulopathy in French Guiana"],"prefix":"10.1371","volume":"17","author":[{"given":"St\u00e9phanie","family":"Houcke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Pujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segolene","family":"Vauquelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy Roger","family":"Lontsi Ngoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Matheus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaubert","family":"NkontCho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Pierre-Demar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabor","family":"Resiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Hommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-0349","authenticated-orcid":true,"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"pntd.0011242.ref001","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s40475-020-00203-4","article-title":"Bothrops Snakebite Envenomings in the Amazon Region.","volume":"7","author":"D Resiere","year":"2020","journal-title":"Curr Trop Med Rep"},{"key":"pntd.0011242.ref002","article-title":"Clinical Features and Management of Snakebite Envenoming in French Guiana.","author":"D Resiere","year":"2020","journal-title":"Toxins (Basel)."},{"key":"pntd.0011242.ref003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2018.04.003","article-title":"Snakebites in French Guiana: Conclusions of an international symposium","volume":"146","author":"H Kallel","year":"2018","journal-title":"Toxicon"},{"key":"pntd.0011242.ref004","first-page":"41","article-title":"La banque des s\u00e9rums antivenimeux (BSA) et la prise en charge des envenimations par serpents exotiques en France.","author":"D Boels","year":"2009","journal-title":"Urgence Pratique"},{"key":"pntd.0011242.ref005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxicon.2018.04.010","article-title":"Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique","volume":"148","author":"D Resiere","year":"2018","journal-title":"Toxicon"},{"key":"pntd.0011242.ref006","first-page":"1","article-title":"Failure of a Mexican antivenom on recovery from snakebite-related coagulopathy in French Guiana.","author":"X Heckmann","year":"2020","journal-title":"Clin Toxicol (Phila)"},{"key":"pntd.0011242.ref007","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1016\/S2214-109X(19)30225-6","article-title":"WHO\u2019s Snakebite Envenoming Strategy for prevention and control","volume":"7","author":"R Minghui","year":"2019","journal-title":"The Lancet Global Health"},{"key":"pntd.0011242.ref008","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0035-9203(92)90114-R","article-title":"South American rattlesnake bite in a Brazilian teaching hospital. 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