{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:38:17Z","timestamp":1789040297647,"version":"build-2803163510"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41901337"],"award-info":[{"award-number":["41901337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41571158"],"award-info":[{"award-number":["41571158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hemorrhagic fever with renal syndrome (HFRS) is a widespread zoonotic disease seriously threatening Chinese residents\u2019 health. HFRS of Weihe Basin remains highly prevalent in recent years and attracts wide attention. With the acceleration of urbanization and related environmental changes, the interaction among anthropogenic activities, environmental factors, and host animals becomes more complicated in this area, which posed increasingly complex challenges for implementing effective prevention measures. Identifying the potential influencing factors of continuous HFRS epidemics in this typical area is critical to make targeted prevention and control strategies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Spatiotemporal characteristics of HFRS epidemic were analyzed based on HFRS case point data in Weihe Basin from 2005 to 2020. MaxEnt models were constructed to explore the main influencing factors of HFRS epidemic based on HFRS data, natural environment factors and socioeconomic factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Results showed that the HFRS epidemics in Weihe Basin were temporally divided into three periods (the relatively stable period, the rapid rising period, and the fluctuating rising period) and were spatially featured by relatively concentrated in the plains alongside the Weihe River. Landscape played controlling effect in this area while land use, vegetation and population in the area interacted with each other and drove the change of HFRS epidemic. The potential high-risk area for HFRS epidemic was 419 km<jats:sup>2<\/jats:sup>, where the HFRS case density reached 12.48 cases\/km<jats:sup>2<\/jats:sup>, especially in the northern plains of Xi\u2019an City.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We suggested that the temporal and spatial variations in the HFRS epidemics, as well as their dominant influencing factors should be adequately considered for making and\/or adjusting the targeted prevention and control strategies on this disease in Weihe Basin.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0011245","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:22:16Z","timestamp":1682356936000},"page":"e0011245","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Spatiotemporal variations and potential influencing factors of hemorrhagic fever with renal syndrome: A case study in Weihe Basin, China"],"prefix":"10.1371","volume":"17","author":[{"given":"Lingli","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-6381","authenticated-orcid":true,"given":"Shujuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"issue":"2","key":"pntd.0011245.ref001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3201\/eid0302.970202","article-title":"Hantaviruses: A global disease problem","volume":"3","author":"C Schmaljohn","year":"1997","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"pntd.0011245.ref002","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1128\/CMR.00062-09","article-title":"A global perspective on hantavirus ecology, epidemiology, and disease.","volume":"23","author":"CB Jonsson","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"pntd.0011245.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10096-011-1456-y","article-title":"A unifying hypothesis and a single name for a complex globally emerging infection","volume":"31","author":"J Clement","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"8","key":"pntd.0011245.ref004","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3201\/eid1608.090470","article-title":"Hantavirus infections in humans and animals, China","volume":"16","author":"YZ Zhang","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"pntd.0011245.ref005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cimid.2007.05.011","article-title":"Hantavirus infection in East Asia","volume":"30","author":"H Kariwa","year":"2007","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"11","key":"pntd.0011245.ref006","first-page":"1447","article-title":"Enlightenment to the prevention and control of hemorrhagic fever with renal syndrome in field training soldiers by analyzing spatial and temporal distribution in China from 2011 to 2020.","volume":"37","author":"CM Liu","year":"2022","journal-title":"Disease Surveillance"},{"issue":"8","key":"pntd.0011245.ref007","first-page":"1049","article-title":"Study on genotype and gene sequence characters of Hantavirus in Baoji.","volume":"32","author":"YF Sun","year":"2016","journal-title":"Occup and Health"},{"key":"pntd.0011245.ref008","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.3390\/ijerph111212129","article-title":"Spatiotemporal heterogeneity analysis of hemorrhagic fever with renal syndrome in China using geographically weighted regression models","volume":"11","author":"SJ Li","year":"2014","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"pntd.0011245.ref009","first-page":"969","article-title":"Evaluation on immune effect of bivalent vaccine of hemorrhagic fever with renal syndrome in Xianyang, Shaanxi, 2009\u20132013.","volume":"29","author":"FY Li","year":"2014","journal-title":"Disease Surveillance"},{"key":"pntd.0011245.ref010","article-title":"Epidemiological characteristics and environmental risk factors of hemorrhagic fever with renal syndrome in Wei River basin, China","author":"X. 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