{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:05:35Z","timestamp":1777309535573,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011248","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"USAID","doi-asserted-by":"crossref","award":["5 U01 GH001003-05"],"award-info":[{"award-number":["5 U01 GH001003-05"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (&lt; 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against<jats:italic>Toxoplasma gondii<\/jats:italic>(<jats:italic>T<\/jats:italic>.<jats:italic>gondii<\/jats:italic>), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (<jats:italic>Treponema pallidum<\/jats:italic>) in mothers. The mean cohort age was 24.5 years. Maternal<jats:italic>T<\/jats:italic>.<jats:italic>gondii<\/jats:italic>IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for<jats:italic>T<\/jats:italic>.<jats:italic>gondii<\/jats:italic>infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for<jats:italic>T<\/jats:italic>.<jats:italic>gondii<\/jats:italic>IgM. Congenital<jats:italic>T<\/jats:italic>.<jats:italic>gondii<\/jats:italic>and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011248","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:37:16Z","timestamp":1682357836000},"page":"e0011248","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017\u20132018"],"prefix":"10.1371","volume":"17","author":[{"given":"Victoria J.","family":"Hicks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Rene\u00e9","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gottschlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Grajeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Balish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevis","family":"Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangeli","family":"Freitas-Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Cord\u00f3n-Rosales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Sagastume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Espinosa-Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren","family":"Cadena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-2275","authenticated-orcid":true,"given":"Terrence Q.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"issue":"11","key":"pntd.0011248.ref001","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrmicro.2016.125","article-title":"Zika virus\u2014reigniting the TORCH","volume":"14","author":"CB Coyne","year":"2016","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"pntd.0011248.ref002","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MOP.0000000000000453","article-title":"Zika virus congenital syndrome, the new Z in TORCHZ? 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