{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:06:10Z","timestamp":1785546370253,"version":"3.56.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011270","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["H2020 734548"],"award-info":[{"award-number":["H2020 734548"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"German Centre for Infection Research","doi-asserted-by":"crossref","award":["ZikApath"],"award-info":[{"award-number":["ZikApath"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011893","name":"Pan American Health Organization","doi-asserted-by":"publisher","award":["SCON2018-00276"],"award-info":[{"award-number":["SCON2018-00276"]}],"id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303953\/2018-7"],"award-info":[{"award-number":["303953\/2018-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308000\/2021-8"],"award-info":[{"award-number":["308000\/2021-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302696\/2021-0"],"award-info":[{"award-number":["302696\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303001\/2018-6"],"award-info":[{"award-number":["303001\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["425997\/2018-9"],"award-info":[{"award-number":["425997\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT-FCx"],"award-info":[{"award-number":["INCT-FCx"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco - FACEPE","award":["BFP-0010-2.11\/22"],"award-info":[{"award-number":["BFP-0010-2.11\/22"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco - FACEPE","award":["APQ-0346-2.09\/19"],"award-info":[{"award-number":["APQ-0346-2.09\/19"]}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["VPPCB-007-FIO-18-2-134"],"award-info":[{"award-number":["VPPCB-007-FIO-18-2-134"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","award":["IAM-005-FIO-22-2-44"],"award-info":[{"award-number":["IAM-005-FIO-22-2-44"]}],"id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The four Dengue viruses (DENV) serotypes were re-introduced in Brazil\u2019s Northeast region in a couple of decades, between 1980\u2019s and 2010\u2019s, where the DENV1 was the first detected serotype and DENV4 the latest. Zika (ZIKV) and Chikungunya (CHIKV) viruses were introduced in Recife around 2014 and led to large outbreaks in 2015 and 2016, respectively. However, the true extent of the ZIKV and CHIKV outbreaks, as well as the risk factors associated with exposure to these viruses remain vague.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a stratified multistage household serosurvey among residents aged between 5 and 65 years in the city of Recife, Northeast Brazil, from August 2018 to February 2019. The city neighborhoods were stratified and divided into high, intermediate, and low socioeconomic strata (SES). Previous ZIKV, DENV and CHIKV infections were detected by IgG-based enzyme linked immunosorbent assays (ELISA). Recent ZIKV and CHIKV infections were assessed through IgG3 and IgM ELISA, respectively. Design-adjusted seroprevalence were estimated by age group, sex, and SES. The ZIKV seroprevalence was adjusted to account for the cross-reactivity with dengue. Individual and household-related risk factors were analyzed through regression models to calculate the force of infection. Odds Ratio (OR) were estimated as measure of effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Principal findings<\/jats:title>\n                    <jats:p>A total of 2,070 residents\u2019 samples were collected and analyzed. The force of viral infection for high SES were lower as compared to low and intermediate SES. DENV seroprevalence was 88.7% (CI95%:87.0\u201390.4), and ranged from 81.2% (CI95%:76.9\u201385.6) in the high SES to 90.7% (CI95%:88.3\u201393.2) in the low SES. The overall adjusted ZIKV seroprevalence was 34.6% (CI95%:20.0\u201350.9), and ranged from 47.4% (CI95%:31.8\u201361.5) in the low SES to 23.4% (CI95%:12.2\u201333.8) in the high SES. The overall CHIKV seroprevalence was 35.7% (CI95%:32.6\u201338.9), and ranged from 38.6% (CI95%:33.6\u201343.6) in the low SES to 22.3% (CI95%:15.8\u201328.8) in the high SES. Surprisingly, ZIKV seroprevalence rapidly increased with age in the low and intermediate SES, while exhibited only a small increase with age in high SES. CHIKV seroprevalence according to age was stable in all SES. The prevalence of serological markers of ZIKV and CHIKV recent infections were 1.5% (CI95%:0.1\u20133.7) and 3.5% (CI95%:2.7\u20134.2), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results confirmed continued DENV transmission and intense ZIKV and CHIKV transmission during the 2015\/2016 epidemics followed by ongoing low-level transmission. The study also highlights that a significant proportion of the population is still susceptible to be infected by ZIKV and CHIKV. The reasons underlying a ceasing of the ZIKV epidemic in 2017\/18 and the impact of antibody decay in susceptibility to future DENV and ZIKV infections may be related to the interplay between disease transmission mechanism and actual exposure in the different SES.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0011270","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T13:26:22Z","timestamp":1688390782000},"page":"e0011270","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Seroprevalence of Dengue, Chikungunya and Zika at the epicenter of the congenital microcephaly epidemic in Northeast Brazil: A population-based survey"],"prefix":"10.1371","volume":"17","author":[{"given":"Cynthia","family":"Braga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina M. T.","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayner V.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F.","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Fatima P. M.","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolline A.","family":"Mariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice N. L.","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A. A.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Frederico C. A.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto D.","family":"Lins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Felix","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jaenisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3826-9358","authenticated-orcid":true,"given":"Ernesto T. A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle F. T.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"issue":"3","key":"pntd.0011270.ref001","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2105\/AJPH.2018.304849","article-title":"Emerging and Reemerging Aedes-Transmitted Arbovirus Infections in the Region of the Americas: Implications for Health Policy","volume":"109","author":"MA Espinal","year":"2019","journal-title":"Am J Public Health"},{"key":"pntd.0011270.ref002","article-title":"PLISA Plataforma de Informaci\u00f3n en Salud para las Am\u00e9ricas","year":"2022","journal-title":"PAHO\/WHO"},{"issue":"6","key":"pntd.0011270.ref003","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3201\/eid2206.160062","article-title":"Microcephaly in Infants, Pernambuco State, Brazil, 2015","volume":"22","author":"Microcephaly Epidemic Research Group","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"pntd.0011270.ref004","article-title":"Seroprevalence, spatial dispersion and factors associated with flavivirus and chikungunya infection in a risk area: a population-based seroprevalence study in Brazil","volume":"20","author":"Alencar CH Barreto FKDA","year":"2020","journal-title":"BMC Infect. Dis"},{"issue":"11","key":"pntd.0011270.ref005","doi-asserted-by":"crossref","first-page":"e0006055","DOI":"10.1371\/journal.pntd.0006055","article-title":"Zika virus displacement by a chikungunya outbreak in Recife, Brazil. PLOS Negl","volume":"11","author":"T Magalhaes","year":"2017","journal-title":"Trop. Dis"},{"issue":"3","key":"pntd.0011270.ref006","article-title":"Chikungunya surveillance in Brazil: challenges in the context of Public Health","volume":"27","author":"NM Silva","year":"2018","journal-title":"Epidemiol Serv Saude"},{"key":"pntd.0011270.ref007","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1590\/s1518-8787.2017051006889","article-title":"Arboviruses emerging in Brazil: challenges for clinic and implications for public health","volume":"51","author":"MR Donalisio","year":"2017","journal-title":"Rev Saude Publica"},{"issue":"10045","key":"pntd.0011270.ref008","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0140-6736(16)30164-7","article-title":"Use of serological surveys to generate key insights into the changing global landscape of infectious disease","volume":"388","author":"CJ Metcalf","year":"2016","journal-title":"Lancet"},{"issue":"1384","key":"pntd.0011270.ref009","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1098\/rstb.1999.0428","article-title":"Transmission dynamics and epidemiology of dengue: insights from age-stratified sero-prevalence surveys","volume":"354","author":"NM Ferguson","year":"1999","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"12","key":"pntd.0011270.ref010","doi-asserted-by":"crossref","first-page":"e0243239","DOI":"10.1371\/journal.pone.0243239","article-title":"Zika, dengue and chikungunya population prevalence in Rio de Janeiro city, Brazil, and the importance of seroprevalence studies to estimate the real number of infected individuals","volume":"15","author":"ARS P\u00e9riss\u00e9","year":"2020","journal-title":"PLoS One"},{"issue":"6","key":"pntd.0011270.ref011","first-page":"605","article-title":"Dengue and dengue hemorrhagic fever in the State of Pernambuco, 1995\u20132006. Rev. Soc. Bras. Med","volume":"40","author":"MT Cordeiro","year":"2007","journal-title":"Trop"},{"issue":"3","key":"pntd.0011270.ref012","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.actatropica.2009.10.021","article-title":"Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife","volume":"113","author":"C Braga","year":"2010","journal-title":"Brazil. Acta Tropica"},{"key":"pntd.0011270.ref013","unstructured":"Secretaria de Sa\u00fade do Recife. Boletim Epidemiol\u00f3gico\u2014Arboviroses transmitidas pelo Aedes aegypti. In: Ger\u00eancia de Vigil\u00e2ncia Epidemiol\u00f3gica [internet]. Recife, Brazil: Secretaria de Sa\u00fade do Recife, Secretaria Executiva de Vigil\u00e2ncia \u00e0 Sa\u00fade; 2016 [cited 07\/07\/2022]. Available at: https:\/\/cievsrecife.files.wordpress.com\/2012\/08\/boletim-de-arboviroses-se-52-1.pdf."},{"key":"pntd.0011270.ref014","unstructured":"Secretaria de Sa\u00fade do Recife. Boletim Epidemiol\u00f3gico\u2014Arboviroses transmitidas pelo Aedes aegypti. In: Ger\u00eancia de Vigil\u00e2ncia Epidemiol\u00f3gica [internet]. Recife, Brazil: Secretaria de Sa\u00fade do Recife, Secretaria Executiva de Vigil\u00e2ncia \u00e0 Sa\u00fade; 2015[cited 07\/07\/2022]. Available at: https:\/\/cievsrecife.files.wordpress.com\/2012\/08\/boletim-de-arboviroses-se-50-30-12-15.pdf"},{"issue":"4","key":"pntd.0011270.ref015","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2105\/AJPH.2016.303113","article-title":"The Epidemic of Zika Virus\u2013Related Microcephaly in Brazil: Detection, Control, Etiology, and Future Scenarios","volume":"106","author":"MG Teixeira","year":"2016","journal-title":".Am. J. Public Health"},{"issue":"10047","key":"pntd.0011270.ref016","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation","volume":"388","author":"GV Franca","year":"2016","journal-title":"Lancet"},{"key":"pntd.0011270.ref017","author":"Brazilian National Institute of Geography and Statistics -IBGE","year":"2010","journal-title":"CidadesIBGE"},{"key":"pntd.0011270.ref018","unstructured":"Brazilian National Institute of Geography and Statistics -IBGE. Sinopse do Censo Demogr\u00e1fico 2010 [internet] Available at: https:\/\/censo2010.ibge.gov.br\/sinopse\/index.php?uf=00&dados=1"},{"issue":"6","key":"pntd.0011270.ref019","first-page":"90","article-title":"R. Review on determining number of Cluster in K-Means Clustering. Int. j. adv. res. comput. sci","volume":"1","author":"TM Kodinariya","year":"2013","journal-title":"manag. stud"},{"issue":"1","key":"pntd.0011270.ref020","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12889-018-5039-z","article-title":"Microcephaly epidemic related to the Zika virus and living conditions in Recife","volume":"18","author":"WV Souza","year":"2018","journal-title":"Northeast Brazil. BMC Public Health"},{"key":"pntd.0011270.ref021","article-title":"A language and environment for statistical computing","author":"RC Team","year":"2020","journal-title":"R Foundation for Statistical Computing. Vienna, Austria: R Core Team R"},{"issue":"11","key":"pntd.0011270.ref022","first-page":"e00069516","article-title":"AmostraBrasil: an R package for household sampling in Brazilian municipalities].","volume":"32","author":"R Cordeiro","year":"2016","journal-title":"Cad Saude Publica"},{"issue":"9","key":"pntd.0011270.ref023","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cmi.2021.05.047","article-title":"Challenges towards serologic diagnostics of emerging arboviruses","volume":"27","author":"C Fischer","year":"2021","journal-title":"Clin Microbiol Infect"},{"issue":"6427","key":"pntd.0011270.ref024","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.aav6618","article-title":"Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region","volume":"363","author":"I Rodriguez-Barraquer","year":"2019","journal-title":"Science"},{"key":"pntd.0011270.ref025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jviromet.2018.04.009","article-title":"Development of antibody biomarkers of long term and recent dengue virus infections","volume":"257","author":"EJM Nascimento","year":"2018","journal-title":"J Virol Methods"},{"issue":"10","key":"pntd.0011270.ref026","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1017\/S0950268818001218","article-title":"Detection of IgG3 antibodies specific to the human immunodeficiency virus type 1 (HIV-1) p24 protein as marker for recently acquired infection","volume":"146","author":"IFT Viana","year":"2018","journal-title":"Epidemiol Infect"},{"issue":"8","key":"pntd.0011270.ref027","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1128\/JCM.00442-17","article-title":"Evaluation of Euroimmun Anti-Zika Virus IgM and IgG Enzyme-Linked Immunosorbent Assays for Zika Virus Serologic Testing","volume":"55","author":"AG L\u2019Huillier","year":"2017","journal-title":"J Clin Microbiol"},{"key":"pntd.0011270.ref028","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jviromet.2018.06.018","article-title":"Multi-laboratory comparison of three commercially available Zika IgM enzyme-linked immunosorbent assays","volume":"260","author":"AJ Basile","year":"2018","journal-title":"J Virol Methods"},{"issue":"5","key":"pntd.0011270.ref029","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1017\/S0950268812001367","article-title":"Force of infection of dengue serotypes in a population-based study in the northeast of Brazil","volume":"141","author":"PMS Castanha","year":"2013","journal-title":"Epidemiol. Infect"},{"issue":"1","key":"pntd.0011270.ref030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4269\/ajtmh.21-1279","article-title":"Two-year Decay of Zika Virus Neutralizing Antibodies in People Living in an Endemic Region in Brazil","volume":"107","author":"T Magalhaes","year":"2022","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0011270.ref031","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jviromet.2018.03.007","article-title":"Development of an anti-dengue NS1 IgG ELISA to evaluate exposure to dengue virus","volume":"257","author":"EJM Nascimento","year":"2018","journal-title":"J Virol Methods"},{"issue":"2","key":"pntd.0011270.ref032","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"pntd.0011270.ref033","first-page":"668","volume-title":"Bayesian data analysis","author":"A. Gelman","year":"2004"},{"issue":"1","key":"pntd.0011270.ref034","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-7622-9-9","article-title":"A tutorial in estimating the prevalence of disease in humans and animals in the absence of a gold standard diagnostic","volume":"9","author":"FI Lewis","year":"2012","journal-title":"Emerg Themes Epidemiol"},{"issue":"4","key":"pntd.0011270.ref035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1214\/ss\/1177011136","article-title":"Inference from Iterative Simulation Using Multiple Sequences","volume":"7","author":"A Gelman","year":"1992","journal-title":"Statistical Science"},{"issue":"4","key":"pntd.0011270.ref036","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General Methods for Monitoring Convergence of Iterative Simulations. J. Comput","volume":"7","author":"SP Brooks","year":"1998","journal-title":"Graph. Stat"},{"issue":"8","key":"pntd.0011270.ref037","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v009.i08","article-title":"Analysis of complex survey samples","volume":"9","author":"T. Lumley","year":"2004","journal-title":"J. Stat. Softw"},{"issue":"4","key":"pntd.0011270.ref038","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0895-7177(90)90057-T","article-title":"A continuous function model for the age-related force of infection","volume":"13","author":"S.M. R Massad E","year":"1990","journal-title":".Math Comput Model"},{"issue":"1","key":"pntd.0011270.ref039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000935","article-title":"From Re-Emergence to Hyperendemicity: The Natural History of the Dengue Epidemic in Brazil. PLOS Negl","volume":"5","author":"I Rodriguez-Barraquer","year":"2011","journal-title":"Trop. Dis"},{"key":"pntd.0011270.ref040","unstructured":"Secretaria de Sa\u00fade do Recife. Boletim Epidemiol\u00f3gico\u2014Arboviroses transmitidas pelo Aedes aegypti. In: Ger\u00eancia de Vigil\u00e2ncia Epidemiol\u00f3gica [internet]. Recife, Brazil: Secretaria de Sa\u00fade do Recife, Secretaria Executiva de Vigil\u00e2ncia \u00e0 Sa\u00fade; 2019 [cited 8\/23\/2022]. Available at: https:\/\/cievsrecife.files.wordpress.com\/2020\/02\/boletim-arbovirose-se-52.pdf"},{"issue":"1","key":"pntd.0011270.ref041","first-page":"16","article-title":"Dengue infection in pregnancy and transplacental transfer of anti-dengue antibodies in Northeast, Brazil. J. Clin","volume":"60","author":"RC Leite","year":"2014","journal-title":"Virol"},{"issue":"10","key":"pntd.0011270.ref042","doi-asserted-by":"crossref","first-page":"e040735","DOI":"10.1136\/bmjopen-2020-040735","article-title":"Age-dependent seroprevalence of dengue and chikungunya: inference from a cross-sectional analysis in Esmeraldas Province in coastal Ecuador","volume":"10","author":"I Chis Ster","year":"2020","journal-title":"BMJ Open"},{"issue":"4","key":"pntd.0011270.ref043","doi-asserted-by":"crossref","first-page":"e0009337","DOI":"10.1371\/journal.pntd.0009337","article-title":"The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis","volume":"15","author":"Z Li","year":"2021","journal-title":"PLOS Negl. Trop. Dis"},{"issue":"3","key":"pntd.0011270.ref044","doi-asserted-by":"crossref","first-page":"e0007246","DOI":"10.1371\/journal.pntd.0007246","article-title":"Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLOS Negl","volume":"13","author":"PMS Castanha","year":"2019","journal-title":"Trop. Dis"},{"issue":"6","key":"pntd.0011270.ref045","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01390-17","article-title":"High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks","volume":"8","author":"EM Netto","year":"2017","journal-title":"mBio"},{"issue":"24","key":"pntd.0011270.ref046","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"MR Duffy","year":"2009","journal-title":"N Engl J Med"},{"issue":"4","key":"pntd.0011270.ref047","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3201\/eid2304.161549","article-title":"Zika Virus Seroprevalence, French Polynesia, 2014\u20132015","volume":"23","author":"M Aubry","year":"2017","journal-title":"Emerg. Infect. Dis"},{"key":"pntd.0011270.ref048","article-title":"Surveillance for Zika, chikungunya and dengue virus incidence and RNAemia in blood donors at four Brazilian blood centers during 2016\u20132019","author":"B Custer","year":"2022","journal-title":"J Infect Dis"},{"issue":"4","key":"pntd.0011270.ref049","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1473-3099(18)30718-7","article-title":"Long-term circulation of Zika virus in Thailand: an observational study","volume":"19","author":"K Ruchusatsawat","year":"2019","journal-title":"Lancet Infect. Dis"},{"key":"pntd.0011270.ref050","unstructured":"Secretaria de Sa\u00fade do Recife. Boletim Epidemiol\u00f3gico\u2014Arboviroses transmitidas pelo Aedes aegypti. In: Ger\u00eancia de Vigil\u00e2ncia Epidemiol\u00f3gica [internet]. Recife, Brazil: Secretaria de Sa\u00fade do Recife, Secretaria Executiva de Vigil\u00e2ncia \u00e0 Sa\u00fade; 2022 [cited 8\/23\/2022]. Available at: https:\/\/cievsrecife.files.wordpress.com\/2022\/01\/boletim-arboviroses-recife_2021_se52.pdf"},{"issue":"5","key":"pntd.0011270.ref051","doi-asserted-by":"crossref","DOI":"10.3390\/v13050744","article-title":"High Incidence of Zika or Chikungunya Infection among Pregnant Women Hospitalized Due to Obstetrical Complications in Northeastern Brazil-Implications for Laboratory Screening in Arbovirus Endemic Area","volume":"13","author":"I Jacques","year":"2021","journal-title":"Viruses"},{"issue":"6","key":"pntd.0011270.ref052","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.4269\/ajtmh.21-0449","article-title":"Co-circulation of Chikungunya Virus during the 2015\u20132017 Zika Virus Outbreak in Pernambuco, Brazil: An Analysis of the Microcephaly Epidemic Research Group Pregnancy Cohort","volume":"106","author":"L Lobkowicz","year":"2022","journal-title":"Am. J. Trop. Med Hyg"},{"key":"pntd.0011270.ref053","doi-asserted-by":"crossref","first-page":"695173","DOI":"10.3389\/fmicb.2021.695173","article-title":"Current Status of Chikungunya in India","volume":"12","author":"Translational Research Consortia for Chikungunya Virus","year":"2021","journal-title":"Front Microbiol"},{"issue":"9","key":"pntd.0011270.ref054","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1590\/0074-02760170124","article-title":"Increased number of deaths during a chikungunya epidemic in Pernambuco, Brazil","volume":"112","author":"M. G. Brito CAAT","year":"2017","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"4","key":"pntd.0011270.ref055","first-page":"e01622","article-title":"Epidemiological evidence for lineage-specific differences in the risk of inapparent chikungunya virus infection","volume":"93","author":"FB Carrillo","year":"2019","journal-title":"J Virol"},{"issue":"4","key":"pntd.0011270.ref056","first-page":"43","article-title":"Genetic determinants of a chikungunya virus outbreak in northeast Brazil. Poster presented at","volume":"107","author":"C Nguyen","year":"2022","journal-title":": Annual Meeting of the American Society of Tropical Medicine & Hygiene."},{"issue":"7","key":"pntd.0011270.ref057","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3201\/eid2607.190846","article-title":"Transmission of Chikungunya Virus in an Urban Slum, Brazil","volume":"26","author":"RO Anjos","year":"2020","journal-title":"Emerg. Infect. Dis"},{"issue":"12","key":"pntd.0011270.ref058","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/infdis\/jiz396","article-title":"Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey","volume":"220","author":"C Flamand","year":"2019","journal-title":"J Infect Dis"},{"issue":"37","key":"pntd.0011270.ref059","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1073\/pnas.1804672115","article-title":"Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua","volume":"115","author":"JV Zambrana","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pntd.0011270.ref060","doi-asserted-by":"crossref","first-page":"e0010416","DOI":"10.1371\/journal.pntd.0010416","article-title":"Risk factors for infection with chikungunya and Zika viruses in southern Puerto Rico: A community-based cross-sectional seroprevalence survey","volume":"16","author":"LE Adams","year":"2022","journal-title":"PLOS Negl. Trop. Dis"},{"issue":"4","key":"pntd.0011270.ref061","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/infdis\/jiaa563","article-title":"Follow-Up Household Serosurvey in Northeast Brazil for Zika Virus: Sexual Contacts of Index Patients Have the Highest Risk for Seropositivity","volume":"223","author":"T Magalhaes","year":"2021","journal-title":"J Infect Dis"},{"issue":"5","key":"pntd.0011270.ref062","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/infdis\/jiab001","article-title":"Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents","volume":"224","author":"JP Aguilar Ticona","year":"2021","journal-title":"J Infect Dis"},{"issue":"9","key":"pntd.0011270.ref063","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/v12090933","article-title":"Sexual Transmission of Arboviruses: A Systematic Review","volume":"12","author":"BJ Blitvich","year":"2020","journal-title":"Viruses"},{"issue":"1","key":"pntd.0011270.ref064","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53062-z","article-title":"Impact of weather seasonality and sexual transmission on the spread of Zika fever","volume":"9","author":"A D\u00e9nes","year":"2019","journal-title":"Sci. Rep"},{"issue":"4","key":"pntd.0011270.ref065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century","volume":"39","author":"DJ Gubler","year":"2011","journal-title":"Trop Med Health"},{"issue":"4","key":"pntd.0011270.ref066","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2021-007735","article-title":"Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections: a systematic literature review and meta-analysis","volume":"7","author":"GM Power","year":"2022","journal-title":"BMJ Glob Health"},{"issue":"4","key":"pntd.0011270.ref067","first-page":"252","article-title":"[Dengue fever in three sanitary districts in the city of Belo Horizonte, Brazil: a population-based seroepidemiological survey, 2006 to 2007].","volume":"27","author":"JE Pessanha","year":"2010","journal-title":"Rev Panam Salud Publica"},{"issue":"1","key":"pntd.0011270.ref068","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-019-4074-4","article-title":"Seroprevalence for dengue virus in a hyperendemic area and associated socioeconomic and demographic factors using a cross-sectional design and a geostatistical approach, state of S\u00e3o Paulo, Brazil.","volume":"19","author":"F Chiaravalloti-Neto","year":"2019","journal-title":"BMC Infect. Dis"},{"issue":"12","key":"pntd.0011270.ref069","doi-asserted-by":"crossref","first-page":"e0006163","DOI":"10.1371\/journal.pntd.0006163","article-title":"Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population","volume":"11","author":"LW Ang","year":"2017","journal-title":"PLOS Negl. Trop. Dis"},{"issue":"7","key":"pntd.0011270.ref070","doi-asserted-by":"crossref","first-page":"538","DOI":"10.47102\/annals-acadmedsg.V37N7p538","article-title":"The 2005 dengue epidemic in Singapore: epidemiology, prevention and control","volume":"37","author":"BK Koh","year":"2008","journal-title":"Ann Acad Med Singap"},{"issue":"3","key":"pntd.0011270.ref071","doi-asserted-by":"crossref","first-page":"e0006298","DOI":"10.1371\/journal.pntd.0006298","article-title":"Spatio-temporal coherence of dengue, chikungunya and Zika outbreaks in Merida, Mexico","volume":"12","author":"D Bisanzio","year":"2018","journal-title":"PLOS Negl. Trop. Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pntd.0011270","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000}}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0011270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:33:08Z","timestamp":1729683188000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0011270"}},"subtitle":[],"editor":[{"given":"Renata Rosito","family":"Tonelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":71,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0011270","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.03.27.23287774","asserted-by":"object"}]},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]}}}