{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:13:47Z","timestamp":1793088827982,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011356","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R015600\/1"],"award-info":[{"award-number":["MR\/R015600\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Dengue is a major public health challenge and a growing problem due to climate change. The release of <jats:italic>Aedes aegypti<\/jats:italic> mosquitoes infected with the intracellular bacterium <jats:italic>Wolbachia<\/jats:italic> is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled <jats:italic>Wolbachia<\/jats:italic> deployments as a form of dengue control in Vietnam\u2013targeted at the highest burden urban areas.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Ten settings within Vietnam were identified as priority locations for potential future <jats:italic>Wolbachia<\/jats:italic> deployments (using a population replacement strategy). The effectiveness of <jats:italic>Wolbachia<\/jats:italic> deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>From the health sector perspective, the <jats:italic>Wolbachia<\/jats:italic> intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of <jats:italic>Wolbachia<\/jats:italic> releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Overall, we found that targeting high burden cities with <jats:italic>Wolbachia<\/jats:italic> deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0011356","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T17:42:02Z","timestamp":1685468522000},"page":"e0011356","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["An economic evaluation of Wolbachia deployments for dengue control in Vietnam"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-3874","authenticated-orcid":true,"given":"Hugo C.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Le","family":"Quyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynold","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Thi","family":"Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"9","key":"pntd.0011356.ref001","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41564-019-0476-8","article-title":"The current and future global distribution and population at risk of dengue","volume":"4","author":"JP Messina","year":"2019","journal-title":"Nature Microbiology"},{"issue":"7361","key":"pntd.0011356.ref002","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature10355","article-title":"The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations","volume":"476","author":"T Walker","year":"2011","journal-title":"Nature"},{"key":"pntd.0011356.ref003","unstructured":"World Mosquito Program. 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