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Several biological characteristics of <jats:italic>Plasmodium vivax<\/jats:italic> contribute to the resilience of this species, including early gametocyte production, both of which lead to efficient malaria transmission to mosquitoes. This study evaluated the impact of currently used drugs on the transmission of <jats:italic>P<\/jats:italic>. <jats:italic>vivax<\/jats:italic>. Participants received one of the following treatments for malaria: i) chloroquine [10 mg\/kg on day 1 and 7.5 mg\/kg on day 2 and 3] co-administered with Primaquine [0.5 mg\/kg\/day for 7 days]; ii) Chloroquine [10 mg\/kg on day 1 and 7.5 mg\/kg on day 2 and 3] co-administered with one-dose of Tafenoquine [300 mg on day 1]; and iii) Artesunate and Mefloquine [100 mg and 200 mg on day 1, 2 and 3] co-administered with Primaquine [0.5 mg\/kg\/day for 14 days]. Patient blood was collected before treatment and 4 h, 24 h, 48 h and 72 h after treatment. 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