{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:54:01Z","timestamp":1774612441263,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p><jats:italic>Bartonella bacilliformis<\/jats:italic> is a Gram-negative, aerobic bacterium and the known causal agent of Carrion\u2019s disease, still considered a neglected disease. There is limited information about the nucleotide sequences of this bacterium in international databases, and few studies have addressed the genetic diversity of <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic>. We analyzed a total of 20 isolates of <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic> from the Peruvian regions of Ancash and Cajamarca. Three genes (<jats:italic>ialB<\/jats:italic>, <jats:italic>gltA<\/jats:italic>, and <jats:italic>rpoB<\/jats:italic>) were sequenced in each isolate and nucleotide sequences retrieved from GenBank (16 <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic> genomes) were also included in the study. All this information was merged in order to obtain clearer evidence of the phylogenetic relationships of <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic>. In the phylogenetic analysis conducted with the concatenated markers, four isolates (B.b-1, B. b-3, B. b- 7, B.b-8) from the Ancash region were observed to form a subgroup different from <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic> type strain KC583, showing dissimilarity levels of 5.96% (<jats:italic>ialB<\/jats:italic>), 3.69% (<jats:italic>gltA<\/jats:italic>) and 3.04% (<jats:italic>rpoB<\/jats:italic>). Our results suggest that <jats:italic>B<\/jats:italic>. <jats:italic>bacilliformis<\/jats:italic> consists of two different subgroups. Future investigations are needed to establish the taxonomic status of these subgroups.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011615","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T17:23:46Z","timestamp":1696958626000},"page":"e0011615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single-nucleotide polymorphisms in ialB, gltA and rpoB genes of Bartonella bacilliformis isolated from patients in endemic Peruvian regions"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-7507","authenticated-orcid":true,"given":"Yanina","family":"Zarate-Sulca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Daphne","family":"Calvay-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Jimenez-Vasquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Acosta-Conchucos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Mendoza-Mujica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"issue":"1","key":"pntd.0011615.ref001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/CMR.05009-11","article-title":"Intruders below the radar: molecular pathogenesis of Bartonella spp","volume":"25","author":"A Harms","year":"2012","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"pntd.0011615.ref002","doi-asserted-by":"crossref","first-page":"36","DOI":"10.20453\/rmh.v19i1.975","article-title":"Actualizaci\u00f3n de la enfermedad de Carri\u00f3n.","volume":"19","author":"C Magui\u00f1a Vargas","year":"2008","journal-title":"Rev Medica Hered."},{"issue":"7","key":"pntd.0011615.ref003","doi-asserted-by":"crossref","first-page":"e2919","DOI":"10.1371\/journal.pntd.0002919","article-title":"Oroya fever and verruga peruana: bartonelloses unique to South America.","volume":"8","author":"MF Minnick","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"pntd.0011615.ref004","doi-asserted-by":"crossref","first-page":"001614","DOI":"10.1099\/jmm.0.001614","article-title":"JMM Profile: Bartonella bacilliformis: a forgotten killer","volume":"71","author":"J. 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