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To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospitals in Bandung, West Java, during 2017\u20132018 were enrolled in a CNS infection study. Cerebrospinal fluid and serum specimens were tested using molecular, serological, and virus isolation platforms for a number of viral and bacteriological agents. Causal pathogens were identified in 10 out of 50 (20%) and included cytomegalovirus (n = 4), <jats:italic>Streptococcus pneumoniae<\/jats:italic> (n = 2), tuberculosis (n = 2), <jats:italic>Salmonella<\/jats:italic> serotype Typhi (n = 1) and dengue virus (n = 1). 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