{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:54:28Z","timestamp":1779126868571,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011786","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000}}],"reference-count":91,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE17-0026"],"award-info":[{"award-number":["ANR-18-CE17-0026"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Hemostasis impairment represents the most threatening consequence of Viperidae envenoming, notably with <jats:italic>Bothrops<\/jats:italic> genus. In the French departments of America, <jats:italic>B<\/jats:italic>. <jats:italic>atrox<\/jats:italic> envenomation in French Guiana may lead to bleeding while <jats:italic>B<\/jats:italic>. <jats:italic>lanceolatus<\/jats:italic> envenomation in Martinique to thrombosis. Bleeding related to <jats:italic>B<\/jats:italic>. <jats:italic>atrox<\/jats:italic> envenomation is attributed to vascular damage mediated by venom metalloproteinases and blood uncoagulable state resulting from thrombocytopenia and consumptive coagulopathy. Thrombosis related to <jats:italic>B<\/jats:italic>. <jats:italic>lanceolatus<\/jats:italic> envenomation are poorly understood. We aimed to compare the effects of <jats:italic>B<\/jats:italic>. <jats:italic>atrox<\/jats:italic> and <jats:italic>B<\/jats:italic>. <jats:italic>lanceolatus<\/jats:italic> venoms in the rat to identify the determinants of the hemorrhagic <jats:italic>versus<\/jats:italic> thrombotic complications. Viscoelastometry (ROTEM), platelet count, plasma fibrinogen, thrombin generation assay, fibrinography, endothelial (von Willebrand factor, ADAMTS13 activity, ICAM-1, and soluble E-selectin), and inflammatory biomarkers (IL-1\u03b2, IL-6, TNF-\u03b1, MCP-1, and PAI-1) were determined in blood samples obtained at H3, H6, and H24 after the subcutaneous venom <jats:italic>versus<\/jats:italic> saline injection. In comparison to the control, initial fibrinogen consumption was observed with the two venoms while thrombocytopenia and reduction in the clot amplitude only with <jats:italic>B<\/jats:italic>. <jats:italic>atrox<\/jats:italic> venom. Moreover, we showed an increase in thrombin generation at H3 with the two venoms, an increase in fibrin generation accompanied with hyperfibrinogenemia at H24 and an increase in inflammatory biomarkers with <jats:italic>B<\/jats:italic>. <jats:italic>lanceolatus<\/jats:italic> venom. No endothelial damage was found with the two venoms. To conclude, our data support two-sided hemostasis complications in <jats:italic>Bothrops<\/jats:italic> envenoming with an initial risk of hemorrhage related to platelet consumption and hypocoagulability followed by an increased risk of thrombosis promoted by the activated inflammatory response and rapid-onset fibrinogen restoration.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011786","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T19:22:54Z","timestamp":1701112974000},"page":"e0011786","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bothrops venom-induced hemostasis disorders in the rat: Between Scylla and 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