{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:10Z","timestamp":1790724490108,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["MR-110-GP-03"],"award-info":[{"award-number":["MR-110-GP-03"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Counsil","award":["MOST 107-2314-B-006-075-MY3"],"award-info":[{"award-number":["MOST 107-2314-B-006-075-MY3"]}]},{"name":"National Science and Technology Counsil","award":["MOST 110-2625-M-006 -009"],"award-info":[{"award-number":["MOST 110-2625-M-006 -009"]}]},{"name":"National Science and Technology Counsil","award":["MOST 111-2625-M-006-016"],"award-info":[{"award-number":["MOST 111-2625-M-006-016"]}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH-11103007"],"award-info":[{"award-number":["NCKUH-11103007"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH-11203040"],"award-info":[{"award-number":["NCKUH-11203040"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Dengue infection can affect the central nervous system and cause various neurological complications. Previous studies also suggest dengue was associated with a significantly increased long-term risk of dementia. A population-based cohort study was conducted using national health databases in Taiwan and included 37,928 laboratory-confirmed dengue patients aged \u2265 45 years between 2002 and 2015, along with 151,712 matched nondengue individuals. Subdistribution hazard regression models showed a slightly increased risk of Alzheimer\u2019s disease, and unspecified dementia, non-vascular dementia, and overall dementia in dengue patients than the nondengue group, adjusted for age, sex, area of residence, urbanization level, income, comorbidities, and all-cause clinical visits within one year before the index date. After considering multiple comparisons using Bonferroni correction, only overall dementia and non-vascular dementia remained statistically significant (adjusted SHR 1.13, 95% CI 1.05\u20131.21, p = 0.0009; E-value 1.51, 95% CI 1.28-NA). Sensitivity analyses in which dementia cases occurring in the first three or five years after the index dates were excluded revealed no association between dengue and dementia. In conclusion, this study found dengue patients had a slightly increased risk of non-vascular dementia and total dementia than those without dengue. However, the small corresponding E-values and sensitivity analyses suggest the association between dengue and dementia may not be causal.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011788","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T18:25:46Z","timestamp":1701887146000},"page":"e0011788","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study"],"prefix":"10.1371","volume":"17","author":[{"given":"Yu-Wen","family":"Chien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-I","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4481-3102","authenticated-orcid":true,"given":"Chia-Yu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"issue":"10169","key":"pntd.0011788.ref001","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"A Wilder-Smith","year":"2019","journal-title":"Lancet"},{"issue":"7446","key":"pntd.0011788.ref002","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"issue":"1","key":"pntd.0011788.ref003","doi-asserted-by":"crossref","first-page":"e2021","DOI":"10.1002\/rmv.2021","article-title":"Research advancements in the neurological presentation of flaviviruses","volume":"29","author":"T Chen","year":"2019","journal-title":"Rev Med Virol"},{"key":"pntd.0011788.ref004","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3389\/fcimb.2017.00449","article-title":"Neurological Manifestations of Dengue Infection","volume":"7","author":"GH Li","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"pntd.0011788.ref005","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1365-3156.2007.01891.x","article-title":"Atypical manifestations of dengue","volume":"12","author":"S Gulati","year":"2007","journal-title":"Trop Med Int Health"},{"issue":"5","key":"pntd.0011788.ref006","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jinf.2021.08.037","article-title":"Dengue and dementia risk: A nationwide longitudinal study","volume":"83","author":"CS Chu","year":"2021","journal-title":"J Infect"},{"issue":"8","key":"pntd.0011788.ref007","doi-asserted-by":"crossref","first-page":"e14318","DOI":"10.1111\/ijcp.14318","article-title":"Incidence of dementia after dengue fever: Results of a longitudinal population-based study","volume":"75","author":"SH Chang","year":"2021","journal-title":"Int J Clin Pract"},{"issue":"7","key":"pntd.0011788.ref008","doi-asserted-by":"crossref","first-page":"e0006533","DOI":"10.1371\/journal.pntd.0006533","article-title":"Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review","volume":"12","author":"C Fritzell","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pntd.0011788.ref009","doi-asserted-by":"crossref","first-page":"e2018062","DOI":"10.4178\/epih.e2018062","article-title":"Data resource profile: the National Health Insurance Research Database (NHIRD)","volume":"40","author":"LY Lin","year":"2018","journal-title":"Epidemiol Health"},{"key":"pntd.0011788.ref010","unstructured":"World Health Organization. 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