{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:08:46Z","timestamp":1767179326149,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011796","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000}}],"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["H3A-18-004"],"award-info":[{"award-number":["H3A-18-004"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals genetically susceptible to high schistosomiasis worm burden may contribute disproportionately to transmission and could be prioritized for control. Identifying genes involved may guide development of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal findings<\/jats:title>\n                    <jats:p>\n                      A cohort of 606 children aged 10\u201315 years were recruited in the Albert Nile region of Uganda and assessed for\n                      <jats:italic>Schistosoma mansoni<\/jats:italic>\n                      worm burden using the Up-Converting Particle Lateral Flow (UCP-LF) test detecting circulating anodic antigen (CAA), point-of-care Circulating Cathodic Antigen (POC-CCA) and Kato-Katz tests. Whole genome genotyping was conducted on 326 children comprising the top and bottom 25% of worm burden. Linear models were fitted to identify variants associated with worm burden in preselected candidate genes. Expression quantitative trait locus (eQTL) analysis was conducted for candidate genes with UCP-LF worm burden included as a covariate. Single Nucleotide Polymorphism loci associated with UCP-LF CAA included\n                      <jats:italic>IL6<\/jats:italic>\n                      rs2066992 (OR = 0.43,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0006) and rs7793163 (OR = 2.0,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0007);\n                      <jats:italic>IL21<\/jats:italic>\n                      SNP kgp513476 (OR 1.79, p = 0.0025) and\n                      <jats:italic>IL17B<\/jats:italic>\n                      SNP kgp708159 (OR = 0.35, p = 0.0028). A haplotype in the\n                      <jats:italic>IL10<\/jats:italic>\n                      locus was associated with lower worm burden (OR = 0.53, p = 0.015) and overlapped SNPs rs1800896, rs1800871 and rs1800872. Significant haplotypes (p&lt;0.05, overlapping significant SNP) associated with worm burden were observed in\n                      <jats:italic>IL6<\/jats:italic>\n                      and the Th17 pathway\n                      <jats:italic>IL12B<\/jats:italic>\n                      and\n                      <jats:italic>IL17B<\/jats:italic>\n                      genes. There were significant eQTL in the\n                      <jats:italic>IL6<\/jats:italic>\n                      ,\n                      <jats:italic>IL5<\/jats:italic>\n                      ,\n                      <jats:italic>IL21<\/jats:italic>\n                      ,\n                      <jats:italic>IL25<\/jats:italic>\n                      and\n                      <jats:italic>IFNG<\/jats:italic>\n                      regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Variants associated with\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>mansoni<\/jats:italic>\n                      worm burden were in\n                      <jats:italic>IL6<\/jats:italic>\n                      ,\n                      <jats:italic>FCN2<\/jats:italic>\n                      ,\n                      <jats:italic>RNASE3<\/jats:italic>\n                      ,\n                      <jats:italic>IL10<\/jats:italic>\n                      ,\n                      <jats:italic>IL12B<\/jats:italic>\n                      and\n                      <jats:italic>IL17B<\/jats:italic>\n                      gene loci. However only eQTL associations remained significant after Bonferroni correction. In summary, immune balance, pathogen recognition and Th17 pathways may play a role in modulating\n                      <jats:italic>Schistosoma<\/jats:italic>\n                      worm burden. Individuals carrying risk variants may be targeted first in allocation of control efforts to reduce the burden of schistosomiasis in the community.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0011796","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T14:14:30Z","timestamp":1701353670000},"page":"e0011796","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda"],"prefix":"10.1371","volume":"17","author":[{"given":"Oscar Asanya","family":"Nyangiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Mulindwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Namulondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kitibwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacent","family":"Nassuuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magambo 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Kaur","family":"Madhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Casacuberta-Partal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-7032","authenticated-orcid":true,"given":"Enock","family":"Matovu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the TrypanoGEN+ Research group of the H3Africa 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