{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:40:58Z","timestamp":1792802458771,"version":"4.5.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>Chagas disease (ChD), caused by infection with the flagellated protozoan, <jats:italic>Trypanosoma cruzi<\/jats:italic>, has a complicated transmission cycle with many infection routes. These include vector-borne (via the triatomine (reduviid bug) vector defecating into a skin abrasion, usually following a blood meal), transplacental transmission, blood transfusion, organ transplant, laboratory accident, and foodborne transmission. Foodborne transmission may occur due to ingestion of meat or blood from infected animals or from ingestion of other foods (often fruit juice) contaminated by infected vectors or secretions from reservoir hosts. Despite the high disease burden associated with ChD, it was omitted from the original World Health Organization estimates of foodborne disease burden that were published in 2015. As these estimates are currently being updated, this review presents arguments for including ChD in new estimates of the global burden of foodborne disease. Preliminary calculations suggest a burden of at least 137,000 Disability Adjusted Life Years, but this does not take into account the greater symptom severity associated with foodborne transmission. Thus, we also provide information regarding the greater health burden in endemic areas associated with foodborne infection compared with vector-borne infection, with higher mortality and more severe symptoms. We therefore suggest that it is insufficient to use source attribution alone to determine the foodborne proportion of current burden estimates, as this may underestimate the higher disability and mortality associated with the foodborne infection route.<\/jats:p>","DOI":"10.1371\/journal.pntd.0011898","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T18:21:34Z","timestamp":1707416494000},"page":"e0011898","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["The importance of estimating the burden of disease from foodborne transmission of Trypanosoma cruzi"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-4421","authenticated-orcid":true,"given":"Lucy J.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-5460","authenticated-orcid":true,"given":"Arie H.","family":"Havelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-2235","authenticated-orcid":true,"given":"Karen H.","family":"Keddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brecht","family":"Devleesschauwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-9983","authenticated-orcid":true,"given":"Paul R.","family":"Torgerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"pntd.0011898.ref001","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5334\/gh.1150","article-title":"Global, regional, and national trends of Chagas disease from 1990 to 2019: comprehensive analysis of the Global Burden of Disease Study","volume":"17","author":"SA G\u00f3mez-Ochoa","year":"2022","journal-title":"Glob Heart"},{"key":"pntd.0011898.ref002","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-319-23410-6_5","volume-title":"Trypanosoma cruzi as a Foodborne Pathogen","author":"O Noya Gonz\u00e1lez","year":"2015"},{"key":"pntd.0011898.ref003","doi-asserted-by":"crossref","first-page":"e1001923","DOI":"10.1371\/journal.pmed.1001923","article-title":"World Health Organization Foodborne Disease Burden Epidemiology Reference Group. 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