{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:40:42Z","timestamp":1767177642201,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011915","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000}}],"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["949963"],"award-info":[{"award-number":["949963"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"\n Background<\/jats:title>\n \n Loa loa<\/jats:italic>\n filariasis (loiasis) is still considered a relatively benign disease. However, recent epidemiologic data suggest increased mortality and morbidity in\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n infected individuals. We aimed to examine whether the density of\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n microfilariae (mfs) in the blood is associated with cardiovascular disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n Using a point-of-care device (pOpm\u00e8tre), we conducted a cross-sectional study to assess arterial stiffness and peripheral arterial disease (PAD) in 991 individuals living in a loiasis-endemic rural area in the Republic of the Congo. Microfilaremic individuals were matched for age, sex and village of residence with 2 amicrofilaremic subjects.<\/jats:p>\n \n We analyzed markers of arterial stiffness (Pulse-Wave Velocity, PWV), PAD (Ankle-Brachial Index, ABI) and cardiovascular health (Pulse Pressure, PP). The analysis considered parasitological results (\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n microfilarial density [MFD], soil-transmitted helminths infection, asymptomatic malaria and onchocerciasis), sociodemographic characteristics and known cardiovascular risk factors (body mass index, smoking status, creatininemia, blood pressure).\n <\/jats:p>\n <\/jats:sec>\n \n Principal findings<\/jats:title>\n \n Among the individuals included in the analysis, 192\/982 (19.5%) and 137\/976 (14.0%) had a PWV or an ABI considered out of range, respectively. Out of range PWV was associated with younger age, high mean arterial pressure and high\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n MFD. Compared to amicrofilaremic subjects, those with more than 10,000 mfs\/mL were 2.17 times more likely to have an out of range PWV (p = 0.00). Factors significantly associated with PAD were older age, low pulse rate, low body mass index, smoking, and\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n microfilaremia. Factors significantly associated with an elevation of PP were older age, female sex, high average blood pressure, low pulse rate and\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n microfilaremia.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A potential link between high\n L<\/jats:italic>\n .\n loa<\/jats:italic>\n microfilaremia and cardiovascular health deterioration is suggested. Further studies are required to confirm and explore this association.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pntd.0011915","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T13:59:23Z","timestamp":1705672763000},"page":"e0011915","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between arterial stiffness and Loa loa microfilaremia in a rural area of the Republic of Congo: A population-based cross-sectional study (the MorLo project)"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-5204","authenticated-orcid":true,"given":"J\u00e9r\u00e9my T.","family":"Campillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Dupasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Lebredonchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic G.","family":"Ranc\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlhand C.","family":"Hemilembolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien D. 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