{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:08:43Z","timestamp":1791248923633,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0011987","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000}}],"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960450"],"award-info":[{"award-number":["81960450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Major Special Science and Technology Project","award":["2017ZX10203207"],"award-info":[{"award-number":["2017ZX10203207"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>We examined the impact of the <jats:italic>Clonorchis sinensis<\/jats:italic> (<jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic>) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Between May 2013 and December 2021, 157 consecutive srHCC patients who underwent hepatectomy were divided into an no <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group (n = 126) and <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group (n = 31). To adjust for differences in preoperative characteristics an inverse probability of treatment weighting (IPTW) analysis was done, using propensity scores. Overall survival (OS) and recurrence-free survival (RFS) were compared before and after IPTW. Multivariate Cox regression analysis was performed to determine whether the <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> infection was an independent prognostic factor after IPTW.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In original cohort, the no <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group did not show a survival advantage over the <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group. After IPTW adjustment, the median OS for the <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group was 9 months, compared to 29 months for the no <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group. <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group have worse OS than no <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> group (p = 0.024), while it did not differ in RFS(p = 0.065). The multivariate Cox regression analysis showed that <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> infection and lower age were associated with worse OS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The <jats:italic>C<\/jats:italic>. <jats:italic>sinensis<\/jats:italic> infection has an adverse impact on os in srHCC patients who underwent hepatectomy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0011987","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T18:32:06Z","timestamp":1708540326000},"page":"e0011987","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting 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