{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:48:13Z","timestamp":1783529293265,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012068","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000}}],"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["No. QRX17121"],"award-info":[{"award-number":["No. QRX17121"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["No. BK20211004"],"award-info":[{"award-number":["No. BK20211004"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanjing Important Science & Technology Specific Projects","award":["No. 2021\u201011005"],"award-info":[{"award-number":["No. 2021\u201011005"]}]},{"name":"the Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University","award":["2022-LCYJ-DBZ-06"],"award-info":[{"award-number":["2022-LCYJ-DBZ-06"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an epidemic emerging infectious disease with high mortality rate. We investigated the association between liver injury and clinical outcomes in patients with SFTS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 291 hospitalized SFTS patients were retrospectively included. Cox proportional hazards model was adopted to identify risk factors of fatal outcome and Kaplan-Meier curves were used to estimate cumulative risks.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>60.1% of patients had liver injury at admission, and the median alanine transaminase, aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBil) levels were 76.4 U\/L, 152.3 U\/L, 69.8 U\/L and 9.9 \u03bcmol\/L, respectively. Compared to survivors, non-survivors had higher levels of AST (253.0 U\/L vs. 131.1 U\/L, P &lt; 0.001) and ALP (86.2 U\/L vs. 67.9 U\/L, P = 0.006), higher proportion of elevated ALP (20.0% vs. 4.4%, P &lt; 0.001) and liver injury (78.5% vs. 54.9%, P = 0.001) at admission. The presence of liver injury (HR 2.049, P = 0.033) at admission was an independent risk factor of fatal outcome.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Liver injury was a common complication and was strongly associated with poor prognosis in SFTS patients. Liver function indicators should be closely monitored for SFTS patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0012068","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T18:29:25Z","timestamp":1713292165000},"page":"e0012068","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of liver function and prognosis in patients with severe fever with thrombocytopenia 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