{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:31:43Z","timestamp":1792481503934,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012117","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000}}],"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010675","name":"H2020 Innovation In SMEs","doi-asserted-by":"publisher","award":["881062"],"award-info":[{"award-number":["881062"]}],"id":[{"id":"10.13039\/100010675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["Edge-Spot project INV-051355"],"award-info":[{"award-number":["Edge-Spot project INV-051355"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["IND2019\/TIC-17167"],"award-info":[{"award-number":["IND2019\/TIC-17167"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003759","name":"Universidad Polit\u00e9cnica de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>\n                    Filariasis, a neglected tropical disease caused by roundworms, is a significant public health concern in many tropical countries. Microscopic examination of blood samples can detect and differentiate parasite species, but it is time consuming and requires expert microscopists, a resource that is not always available. In this context, artificial intelligence (AI) can assist in the diagnosis of this disease by automatically detecting and differentiating microfilariae. In line with the target product profile for lymphatic filariasis as defined by the World Health Organization, we developed an edge AI system running on a smartphone whose camera is aligned with the ocular of an optical microscope that detects and differentiates filarias species in real time without the internet connection. Our object detection algorithm that uses the Single-Shot Detection (SSD) MobileNet V2 detection model was developed with 115 cases, 85 cases with 1903 fields of view and 3342 labels for model training, and 30 cases with 484 fields of view and 873 labels for model validation before clinical validation, is able to detect microfilariae at 10x magnification and distinguishes four species of them at 40x magnification:\n                    <jats:italic>Loa loa<\/jats:italic>\n                    ,\n                    <jats:italic>Mansonella perstans<\/jats:italic>\n                    ,\n                    <jats:italic>Wuchereria bancrofti<\/jats:italic>\n                    , and\n                    <jats:italic>Brugia malayi<\/jats:italic>\n                    . We validated our augmented microscopy system in the clinical environment by replicating the diagnostic workflow encompassed examinations at 10x and 40x with the assistance of the AI models analyzing 18 samples with the AI running on a middle range smartphone. It achieved an overall precision of 94.14%, recall of 91.90% and F1 score of 93.01% for the screening algorithm and 95.46%, 97.81% and 96.62% for the species differentiation algorithm respectively. This innovative solution has the potential to support filariasis diagnosis and monitoring, particularly in resource-limited settings where access to expert technicians and laboratory equipment is scarce.\n                  <\/jats:p>","DOI":"10.1371\/journal.pntd.0012117","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T13:53:43Z","timestamp":1713362023000},"page":"e0012117","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Edge Artificial Intelligence (AI) for real-time automatic quantification of filariasis in mobile 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