{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T18:33:59Z","timestamp":1767119639979,"version":"3.48.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chikungunya is an emerging vector-borne disease of global significance, known for causing acute illness characterized by fever and severe arthralgia, which can evolve to chronic arthritis and rheumatism especially in elderly patients. While febrile illness and arthralgia are common clinical presentations among residents of Mount Elgon (Mt. Elgon), the role of chikungunya virus as a causative agent is undocumented. This study aimed to assess the prevalence of antibodies against Chikungunya Virus (CHIKV) antigens in patients presenting with acute febrile illnesses (AFI) in Mt. Elgon region, Kenya.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional seroprevalence study involved febrile patients visiting selected health facilities in the region. Serum samples were collected and screened for 1gG\u2009+\u2009IgM\u2009+\u2009IgA antibodies using an indirect Enzyme Linked Immunosorbent Assay (ELISA). Positive samples were further analyzed using standard plaque reduction neutralization assay (PRNT) on Vero (Biken) E6 cell cultures for confirmation of presence of neutralizing antibodies against CHIKV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ELISA results indicated that 317\/1359 (23.33%) serum samples were positive for CHIKV antibodies. Of these, 305 samples (96.21%) were subjected to PRNT, 127 samples (9.3%) tested positive for CHIKV neutralizing antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate active circulation of CHIKV in Mt. Elgon region. This underscores the need for enhanced surveillance and monitoring strategies to mitigate the risk of potential outbreaks in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pntd.0012169","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T18:31:21Z","timestamp":1767119481000},"page":"e0012169","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chikungunya virus seroprevalence among febrile patients in selected health facilities in Mount Elgon region, Kenya"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2645-9687","authenticated-orcid":true,"given":"Sheila","family":"Kageha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce Mwongeli","family":"Ngoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses Matilu","family":"Mwau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"issue":"1","key":"pntd.0012169.ref001","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0042-6822(67)90093-1","article-title":"Electron microscope study of development of Chikungunya virus in green monkey kidney stable (VERO) cells","volume":"33","author":"N Higashi","year":"1967","journal-title":"Virology"},{"issue":"21","key":"pntd.0012169.ref002","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1128\/JVI.75.21.10118-10131.2001","article-title":"Evolutionary relationships and systematics of the alphaviruses","volume":"75","author":"AM Powers","year":"2001","journal-title":"J Virol"},{"issue":"3","key":"pntd.0012169.ref003","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/mr.58.3.491-562.1994","article-title":"The alphaviruses: gene expression, replication, and evolution","volume":"58","author":"JH Strauss","year":"1994","journal-title":"Microbiol Rev"},{"issue":"4","key":"pntd.0012169.ref004","first-page":"151","article-title":"Emergence of chikungunya virus in Indian subcontinent after 32 years: A review","volume":"43","author":"C Lahariya","year":"2006","journal-title":"J Vector Borne Dis"},{"issue":"1","key":"pntd.0012169.ref005","first-page":"28","article-title":"An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. 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