{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:00:01Z","timestamp":1792130401862,"version":"4.4.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Tennessee Department of Entomology & Plant Pathology"},{"name":"Epidemiology and Laboratory Capacity for Prevention and Control of Emerging Infectious Diseases","award":["NU50CK000530"],"award-info":[{"award-number":["NU50CK000530"]}]},{"name":"Epidemiology and Laboratory Capacity for Prevention and Control of Emerging Infectious Diseases","award":["NU50CK000528"],"award-info":[{"award-number":["NU50CK000528"]}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:p>The combined region of eastern Tennessee and western North Carolina has a persistently high risk of pediatric La Crosse virus neuroinvasive disease (LACV-ND). To guide public health intervention in this region, the objectives of this retrospective ecological study were to investigate the geographic clustering and predictors of pediatric LACV-ND risk at the ZIP code tabulation area (ZCTA) level. Data on pediatric cases of LACV-ND reported between 2003 and 2020 were obtained from Tennessee Department of Health and North Carolina Department of Health and Human Services. Purely spatial and space-time scan statistics were used to identify ZCTA-level clusters of confirmed and probable pediatric LACV-ND cases from 2003\u20132020, and a combination of global and local (i.e., geographically weighted) negative binomial regression models were used to investigate potential predictors of disease risk from 2015\u20132020. The cluster investigation revealed spatially persistent high-risk and low-risk clusters of LACV-ND, with most cases consistently reported from a few high-risk clusters throughout the entire study period. Temperature and precipitation had positive but antagonistic associations with disease risk from 2015\u20132020, but the strength of those relationships varied substantially across the study area. Because LACV-ND risk clustering in this region is focally persistent, retroactive case surveillance can be used to guide the implementation of targeted public health intervention to reduce the disease burden in high-risk areas. Additional research on the role of climate in LACV transmission is warranted to support the development of predictive transmission models to guide proactive public health interventions.<\/jats:p>","DOI":"10.1371\/journal.pntd.0012186","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:45:19Z","timestamp":1717695919000},"page":"e0012186","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Persistent spatial clustering and predictors of pediatric La Crosse virus neuroinvasive disease risk in eastern Tennessee and western North Carolina, 2003\u20132020"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-6140","authenticated-orcid":true,"given":"Corey A.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agricola 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Kulldorf","year":"2021","journal-title":"SatScan user guide for version 10.0 [Internet]."},{"issue":"3","key":"pntd.0012186.ref051","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.3390\/ijerph110303256","article-title":"A tale of two city blocks: differences in immature and adult mosquito abundances between socioeconomically different urban blocks in Baltimore (Maryland, USA).","volume":"11","author":"B Becker","year":"2014","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pntd.0012186.ref052","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.20-0829","article-title":"Role of abandoned and vacant houses on Aedes aegypti productivity","volume":"104","author":"R Barrera","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"pntd.0012186.ref053","article-title":"Technical documentation: 2020 TIGER\/Line shapefiles technical documentation [Internet].","author":"United States Census Bureau","year":"2020"},{"issue":"1","key":"pntd.0012186.ref054","doi-asserted-by":"crossref","first-page":"34","DOI":"10.52707\/1081-1710-46.1.34","article-title":"Peridomestic conditions affect La Crosse virus entomological risk by modifying the habitat use patterns of its mosquito vectors.","volume":"46","author":"TT Tamini","year":"2021","journal-title":"J Vector Ecol"},{"issue":"1","key":"pntd.0012186.ref055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1948-7134.2009.00009.x","article-title":"The mosquitoes of eastern Tennessee: studies on abundance, habitat preferences, and host-seeking behaviors.","volume":"34","author":"AD Haddow","year":"2009","journal-title":"J Vector Ecol"},{"issue":"6","key":"pntd.0012186.ref056","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/jmedent\/44.6.945","article-title":"Establishment and abundance of a recently introduced mosquito species Ochlerotatus japonicus (Diptera: Culicidae) in the southern Appalachians, USA.","volume":"44","author":"SN Bevins","year":"2007","journal-title":"J Med Entomol"},{"key":"pntd.0012186.ref057","volume-title":"National Land Cover Database (NLCD) 2019 Products (ver. 2.0, June 2021):","author":"J. 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Charlottetown","author":"I Dohoo","year":"2012"},{"key":"pntd.0012186.ref065","article-title":"A SAS macro for geographically weighted negative binomial regression [Internet].","author":"A da Silva","year":"2016"},{"issue":"5","key":"pntd.0012186.ref066","first-page":"769","article-title":"Geographically weighted negative binomial regression\u2014incorporating overdispersion.","volume":"24","author":"AR da Silva","year":"2014","journal-title":"Stat Comput."},{"key":"pntd.0012186.ref067","volume-title":"SAS Version 9.4","author":"SAS Institute Inc","year":"2013"},{"key":"pntd.0012186.ref068","volume-title":"Charlton. 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