{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:13:18Z","timestamp":1792131198018,"version":"4.4.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST-111-2625-M-006 -016 -"],"award-info":[{"award-number":["MOST-111-2625-M-006 -016 -"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MR-110-GP-03"],"award-info":[{"award-number":["MR-110-GP-03"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MR-111-GP-05"],"award-info":[{"award-number":["MR-111-GP-05"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cheng Kung Universit"},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH-11203040 and NCKUH-11303018"],"award-info":[{"award-number":["NCKUH-11203040 and NCKUH-11303018"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Dengue virus (DENV) infection, a common mosquito-borne disease, has been linked to several mental disorders like depression and anxiety. However, the temporal risk of these disorders after DENV infection is not well studied.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This population-based cohort study encompassed 45,334 recently lab-confirmed dengue patients in Taiwan spanning 2002 to 2015, matched at a 1:5 ratio with non-dengue individuals based on age, gender, and residence (n = 226,670). Employing subdistribution hazard regression analysis, we assessed the immediate (&lt;3 months), intermediate (3\u201312 months), and prolonged (&gt;12 months) risks of anxiety disorders, depressive disorders, and sleep disorders post DENV infection. Corrections for multiple comparisons were carried out using the Benjamini-Hochberg procedure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A significant increase in depressive disorder risk across all timeframes post-infection was observed (&lt;3 months [aSHR 1.90, 95% CI 1.20\u20132.99], 3\u201312 months [aSHR 1.68, 95% CI 1.32\u20132.14], and &gt;12 months [aSHR 1.14, 95% CI 1.03\u20131.25]). Sleep disorder risk was higher only during 3\u201312 months (aSHR 1.55, 95% CI 1.18\u20132.04). No elevated anxiety disorder risk was found. Subgroup analysis of hospitalized dengue patients showed increased risk of anxiety disorders within 3 months (aSHR 2.14, 95% CI 1.19\u20133.85) and persistent risk of depressive disorders across all periods. Hospitalized dengue patients also had elevated sleep disorder risk within the first year.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Dengue patients exhibited significantly elevated risks of depressive disorders in both the short and long term. However, dengue\u2019s impact on sleep disorders and anxiety seems to be short-lived. Further research is essential to elucidate the underlying mechanisms.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0012239","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T17:23:18Z","timestamp":1720027398000},"page":"e0012239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever: A nationwide, population-based cohort study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1103-8675","authenticated-orcid":true,"given":"Hsin-I","family":"Shih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-8751","authenticated-orcid":true,"given":"Yu-Wen","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"issue":"1","key":"pntd.0012239.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/2231-0762.175416","article-title":"Dengue virus: A global human threat: Review of literature","volume":"6","author":"S Hasan","year":"2016","journal-title":"J Int Soc Prev Community Dent"},{"issue":"4","key":"pntd.0012239.ref002","doi-asserted-by":"crossref","first-page":"e0267186","DOI":"10.1371\/journal.pone.0267186","article-title":"Risk and predictive factors for severe dengue infection: A systematic review and meta-analysis","volume":"17","author":"K Yuan","year":"2022","journal-title":"PLoS One"},{"issue":"4 Suppl","key":"pntd.0012239.ref003","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2149\/tmh.2011-S10","article-title":"Clinical Manifestations and Management of Dengue\/DHF\/DSS","volume":"39","author":"S. 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