{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:26:24Z","timestamp":1776763584747,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pntd.0012253","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000}}],"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The long-term mortality and morbidity of patients with severe fever with thrombocytopenia syndrome (SFTS) remain unclear.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This retrospective cohort study was conducted using the National Health Insurance Service dataset on hospitalized patients with SFTS aged \u226520 years between 2016 and 2021 (n = 1,217). Each SFTS case was matched with three controls hospitalized for non-SFTS-related diseases using propensity score matching. The all-cause mortality of patients with SFTS was evaluated during the one-year follow-up and compared with that of controls. Post-discharge events were investigated to determine the effects of SFTS on post-acute sequelae.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Finally, 1,105 patients with SFTS and 3,315 controls were included. Patients with SFTS had a higher risk of death during the one-year follow-up than that of controls (hazard ratio [HR], 2\u00b726; 95% confidence interval [CI], 1\u00b782\u20132\u00b781). Thirty-day mortality was significantly higher in the SFTS group (HR, 3\u00b799; 95% CI, 3\u00b707\u20135\u00b719) than in the control group. An increased risk of death after 31\u2013365 days was observed among controls, though this difference was significant only among patients in their 80s (HR, 0\u00b718; 95% CI, 0\u00b706\u20130\u00b757). For post-discharge events, patients in the SFTS group exhibited a higher risk of readmission (HR, 1\u00b717; 95% CI, 1\u00b704\u20131\u00b732) and emergency room visit (HR, 2\u00b732; 95% CI, 1\u00b796\u20132\u00b776) than those in the control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>SFTS induces a higher risk of short-term mortality and post-acute sequelae in hospitalized patients during a one-year follow-up than non-SFTS-related diseases. Our results provide guidance for the management of SFTS.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pntd.0012253","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T17:38:36Z","timestamp":1718386716000},"page":"e0012253","update-policy":"https:\/\/doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea"],"prefix":"10.1371","volume":"18","author":[{"given":"Namwoo","family":"Heo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok-Jae","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonju","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-7906","authenticated-orcid":true,"given":"Yong Chan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"16","key":"pntd.0012253.ref001","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China.","volume":"364","author":"X-J Yu","year":"2011","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"pntd.0012253.ref002","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/cid\/cir732","article-title":"A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission","volume":"53","author":"CJ Bao","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"11","key":"pntd.0012253.ref003","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/cid\/civ128","article-title":"Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea","volume":"60","author":"WY Kim","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"8","key":"pntd.0012253.ref004","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1473-3099(14)70718-2","article-title":"Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis","volume":"14","author":"Q Liu","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"pntd.0012253.ref005","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/infdis\/jis472","article-title":"Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients","volume":"206","author":"ZT Gai","year":"2012","journal-title":"J Infect Dis"},{"issue":"11","key":"pntd.0012253.ref006","first-page":"1892","article-title":"Severe fever with thrombocytopenia syndrome, South Korea, 2012","volume":"19","author":"KH Kim","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"pntd.0012253.ref007","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan","volume":"209","author":"T Takahashi","year":"2014","journal-title":"J Infect Dis"},{"issue":"5","key":"pntd.0012253.ref008","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam","volume":"25","author":"XC Tran","year":"2019","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"pntd.0012253.ref009","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/22221751.2019.1710436","article-title":"The first discovery of severe fever with thrombocytopenia syndrome virus","volume":"9","author":"TL Lin","year":"2020","journal-title":"Taiwan. 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